Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 6/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.50 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.41 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.40 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | LTK | P29376 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.39 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25747870 | 0.85 | XDH (0.38) | PDE4APDE4BPDE4CPDE4DPTPN11 | |
| SCHEMBL31347273 | 0.85 | PDGFRB (0.44) | PTPN11 | |
| SCHEMBL25747758 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMKNK1 | |
| SCHEMBL25040492 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMKNK1 | |
| SCHEMBL25040493 | 0.85 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DMKNK1 | |
| SCHEMBL25040920 | 0.82 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMKNK1 | |
| SCHEMBL23499617 | 0.81 | MMP3 (0.44) | PDE4B | |
| SCHEMBL25040494 | 0.76 | PDE4A (0.43) | PDE4APDE4BPDE4CPDE4DLTK | |
| SCHEMBL6832472 | 0.74 | PARP10 (0.67) | PARP10 | |
| SCHEMBL9448595 | 0.74 | SMPD1 (0.46) | PDE4APDE4BPDE4CPDE4DPARP10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230278956-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-09-07 | — | — | US | disclosed |
| US-20230278956-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-09-07 | — | — | US | disclosed |
| US-11691946-B2 | Preparation of Trifarotene and intermediates and polymorphs thereof | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-07-04 | — | — | US | disclosed |
| US-11691946-B2 | Preparation of Trifarotene and intermediates and polymorphs thereof | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-07-04 | — | — | US | disclosed |
| US-20230051259-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | TARO PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230051259-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | UGT1A4, TBK1, UGT1A7 | PDE4A 934/4885PDE4B 1192/4885PDE4C 1833/4885 |
| US-20230278956-A1 | PREPARATION OF TRIFAROTENE AND INTERMEDIATES AND POLYMORPHS THEREOF | UGT1A4, TBK1, UGT1A7 | PDE4A 934/4885PDE4B 1192/4885PDE4C 1833/4885 |
| US-11691946-B2 | Preparation of Trifarotene and intermediates and polymorphs thereof | UGT1A4, TBK1, UGT1A7 | PDE4A 934/4885PDE4B 1192/4885PDE4C 1833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.