Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.53 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.53 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 5/20 | 0.50 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.50 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | TYK2 | P29597 | 2/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25311520 | 0.87 | HCAR3 (0.58) | MAPK10MAPK8JAK2TYK2AURKA | |
| SCHEMBL14254327 | 0.86 | MAPK8 (0.59) | ROCK1PRKD1PRKD2MAPKAPK2MAPK10 | |
| SCHEMBL18086904 | 0.84 | JAK2 (0.52) | ROCK1MAPK10JAK2TYK2JAK3 | |
| SCHEMBL29818054 | 0.80 | MAPK3 (0.48) | ROCK1PRKD2MAPK10MAPK8JAK2 | |
| SCHEMBL2606609 | 0.76 | NNMT (0.56) | ROCK1TYK2AURKAHCAR3 | |
| SCHEMBL22458668 | 0.76 | ABL1 (0.70) | ROCK1 | |
| SCHEMBL10837371 | 0.75 | ROCK1 (0.59) | ROCK1MAPK10MAPK8JAK2AURKA | |
| SCHEMBL14607583 | 0.75 | HCAR3 (0.76) | JAK2TYK2AURKAJAK3IRAK4 | |
| SCHEMBL27603159 | 0.75 | PLAU (0.57) | — | |
| SCHEMBL4920277 | 0.75 | NPC1 (0.65) | MAPK8MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307376-B1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK PATENT GMBH (DE) | 2015-11-04 | — | — | EP | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-8889719-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| CN-102099336-B | Phenylaminoisonicotinamide compounds | MERCK SERONO SA | 2013-11-06 | — | — | CN | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| EP-2588452-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | Merck Patent GmbH (DE) | 2013-05-08 | — | — | EP | disclosed |
| US-20130102640-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-04-25 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-8404725-B2 | Phenylamino isonicotinamide compounds | MERCK PATENT GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| WO-2012000598-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | MERCK PATENT GMBH (DE) | 2012-01-05 | — | — | WO | disclosed |
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MERCK PATENT GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
| CN-102099336-A | Novel phenylamino isonicotinamide compounds | MERCK SERONO SA | 2011-06-15 | — | — | CN | disclosed |
| EP-2307376-A1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | Merck Patent GmbH (DE) | 2011-04-13 | — | — | EP | disclosed |
| WO-2010017051-A1 | NOVEL PHENYLAMINO ISONICOTINAMIDE COMPOUNDS | MERCK SERONO S.A. (CH) | 2010-02-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110184032-A1 | Novel Phenylamino Isonicotinamide Compounds | MKI67, FGFR1, IGF1R | ROCK1 1874/4885PRKD1 3329/4885PRKD2 3199/4885 |
| US-20130102640-A1 | METHOD FOR THE PREPARATION OF CIS-1,2-DIOLS IN THE KILOGRAM SCALE | ADH1C, DEGS1, MAN1B1 | ROCK1 2441/4885PRKD1 1160/4885PRKD2 2297/4885 |
| US-20130184314-A1 | Novel Phenylamino Isonicotinamide Compounds | MKI67, FGFR1, IGF1R | ROCK1 1874/4885PRKD1 3329/4885PRKD2 3199/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.