Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 1/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 8/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 7/20 | 0.37 |
| ▸ | NAE1 | Q13564 | 2/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.33 |
| ▸ | UBA6 | A0AVT1 | 1/20 | 0.33 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.33 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.33 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.33 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25046760 | 0.84 | PRMT5 (0.40) | PRMT5WDR77 | |
| SCHEMBL25048154 | 0.84 | PDE2A (0.36) | PIP4K2AYTHDC1 | |
| SCHEMBL25047711 | 0.78 | PRMT5 (0.45) | PRMT5WDR77 | |
| SCHEMBL10293822 | 0.77 | PIP4K2A (0.49) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL25048531 | 0.77 | YTHDC1 (0.47) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL17875203 | 0.76 | PRMT5 (0.47) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL23892256 | 0.73 | PIP4K2A (0.43) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL25048059 | 0.72 | CHKA (0.32) | — | |
| SCHEMBL2740590 | 0.69 | NAE1 (0.50) | PIP4K2AYTHDC1PRMT5WDR77NAE1 | |
| SCHEMBL25047920 | 0.68 | PIP4K2A (0.39) | PIP4K2AYTHDC1PRMT5WDR77NAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023017152-A1 | SPECIFIC SMALL MOLECULE INHIBITORS THAT BLOCK KMT9 METHYLTRANSFERASE ACTIVITY AND FUNCTION | ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG (DE) | 2023-02-16 | — | — | WO | disclosed |