Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | ESR1 | P03372 | 2/20 | 0.33 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.32 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.32 |
| ▸ | IKZF2 | Q9UKS7 | 3/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | ITK | Q08881 | 1/20 | 0.32 |
| ▸ | PLK4 | O00444 | 2/20 | 0.32 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25059028 | 0.83 | CRBN (0.56) | CRBNARESR1IKZF3DDB1 | |
| SCHEMBL22692241 | 0.79 | CRBN (0.43) | CRBNARESR1IKZF3DDB1 | |
| SCHEMBL20046716 | 0.78 | CRBN (0.41) | CRBNARESR1IKZF3DDB1 | |
| SCHEMBL26754973 | 0.77 | CRBN (0.43) | CRBNARESR1IKZF3DDB1 | |
| SCHEMBL22565718 | 0.77 | CRBN (0.50) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL20076201 | 0.76 | CRBN (0.53) | CRBNIKZF3DDB1DRD2ADRA1D | |
| SCHEMBL20046709 | 0.75 | CRBN (0.43) | CRBNARESR1IKZF3DDB1 | |
| SCHEMBL22047521 | 0.74 | CRBN (0.47) | CRBNARIKZF3DDB1IKZF2 | |
| SCHEMBL22873401 | 0.72 | CRBN (0.53) | CRBNIKZF3DDB1IKZF2IKZF1 | |
| SCHEMBL20046596 | 0.72 | CRBN (0.51) | CRBNIKZF3DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660004-B1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ANDROGEN RECEPTOR | ARVINAS OPERATIONS INC (US) | 2023-02-22 | — | — | EP | disclosed |