Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDO2 | P48775 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791798 | 0.84 | PKM (0.64) | TDO2ALDH1A1LMNASMN1; SMN2CXCR4 | |
| SCHEMBL17308350 | 0.81 | PRMT5 (0.45) | TDO2ALDH1A1CYP2D6 | |
| SCHEMBL17303504 | 0.80 | PRMT5 (0.45) | TDO2ALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL18672997 | 0.80 | PRMT5 (0.45) | TDO2ALDH1A1CYP2C19CYP2D6 | |
| SCHEMBL17346 | 0.79 | L3MBTL1 (0.51) | ALDH1A1LMNAPOLBGAACYP2D6 | |
| Hydrochloric Acid SCHEMBL16426 | 0.78 | L3MBTL1 (0.50) | ALDH1A1LMNAPOLBGAACYP2D6 | |
| Hydrochloric Acid SCHEMBL16427 | 0.78 | L3MBTL1 (0.50) | ALDH1A1LMNAPOLBGAACYP2D6 | |
| SCHEMBL28273224 | 0.78 | PKM (0.46) | ALDH1A1LMNASMN1; SMN2POLBGAA | |
| SCHEMBL6298944 | 0.77 | TDO2 (0.52) | TDO2CXCR4 | |
| SCHEMBL28696122 | 0.75 | POLB (0.44) | ALDH1A1LMNASMN1; SMN2POLBGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3498701-B1 | PRMT5 INHIBITORS AND USES THEREOF | EPIZYME INC (US) | 2023-02-22 | — | — | EP | disclosed |