Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.53 |
| ▸ | TTK | P33981 | 6/20 | 0.53 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.53 |
| ▸ | ILK | Q13418 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 4/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | AKT1 | P31749 | 1/20 | 0.50 |
| ▸ | AKT2 | P31751 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 3/20 | 0.48 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19398639 | 0.84 | AKT1 (0.50) | LRRK2TTKMAPK8ROCK2AKT1 | |
| SCHEMBL21359338 | 0.80 | KDM1A (0.48) | ROCK2ROCK1AKT1AKT2 | |
| SCHEMBL19406195 | 0.80 | AKT2 (0.53) | TTKMAPK8ILKROCK2ROCK1 | |
| SCHEMBL30424015 | 0.78 | AKT2 (0.71) | ILKROCK2AKT1AKT2 | |
| SCHEMBL28032548 | 0.78 | CA2 (0.73) | LRRK2TTKCA2CA1CA9 | |
| SCHEMBL1926937 | 0.75 | CA2 (0.67) | LRRK2TTKCA2CA1CA9 | |
| SCHEMBL20597906 | 0.74 | AKT2 (0.59) | ILKROCK2ROCK1AKT1AKT2 | |
| SCHEMBL980068 | 0.74 | CHEK1 (0.59) | ROCK2AKT1AKT2 | |
| SCHEMBL14075569 | 0.73 | CA9 (0.70) | LRRK2TTKCDK8CA2CA1 | |
| SCHEMBL16416958 | 0.73 | CHEK1 (0.58) | ROCK2AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | UNIV YALE (US) | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230057076-A1 | Pyrazole-Containing Macrophage Migration Inhibitory Factor Inhibitors | MIF, MMP12, CSF1R | LRRK2 844/4885TTK 2345/4885MAPK8 2359/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.