Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | CRHBP | P24387 | 1/20 | 0.62 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24848629 | 0.89 | CYP3A4 (0.59) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL18068094 | 0.87 | CYP3A4 (0.50) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL25930993 | 0.82 | CYP3A4 (0.44) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL807740 | 0.80 | CYP3A4 (0.44) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL798992 | 0.80 | CYP2C19 (0.62) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL22767093 | 0.78 | CYP2C19 (0.61) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL2717883 | 0.78 | NOS3 (0.50) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL3293782 | 0.78 | HSP90AA1 (0.43) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL20211619 | 0.77 | CYP2C19 (1.00) | CYP2C19CYP3A4CYP2D6TSHRCRHBP | |
| SCHEMBL21212137 | 0.76 | CYP3A4 (0.58) | CYP2C19CYP3A4CYP2D6TSHRCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230055237-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB, LLC | 2023-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230055237-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, MPST, CRAT | CYP2C19 705/4885CYP3A4 791/4885CYP2D6 1129/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.