Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26497685 | 0.91 | HSD11B1 (0.47) | HSD11B1ALDH1A1HTR1AHTR7GAA | |
| SCHEMBL27055677 | 0.89 | HSD11B1 (0.43) | HSD11B1ALDH1A1HTR1AHTR7POLB | |
| SCHEMBL25075495 | 0.88 | NPC1 (0.42) | HSD11B1ALDH1A1HTR1AHTR7POLB | |
| SCHEMBL26494182 | 0.85 | HRH3 (0.43) | ALDH1A1HTR1AHTR7KDM4EELANE | |
| SCHEMBL25075110 | 0.82 | GNAI3 (0.41) | HSD11B1ALDH1A1ELANE | |
| SCHEMBL25075118 | 0.80 | NPC1 (0.41) | HSD11B1ALDH1A1POLBELANEMEN1 | |
| SCHEMBL26494345 | 0.80 | NPC1 (0.41) | HSD11B1ALDH1A1POLBELANEMEN1 | |
| SCHEMBL25075107 | 0.80 | NPC1 (0.41) | HSD11B1ALDH1A1POLBELANEMEN1 | |
| SCHEMBL26494176 | 0.79 | NPC1 (0.47) | HSD11B1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL26496248 | 0.78 | HRH3 (0.40) | HSD11B1ALDH1A1HTR1AHTR7POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |