Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNAI3 | P08754 | 5/20 | 0.41 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.41 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 4/20 | 0.34 |
| ▸ | ITGA2B | P08514 | 4/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25075495 | 0.91 | NPC1 (0.42) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL26494345 | 0.84 | NPC1 (0.41) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL25075118 | 0.84 | NPC1 (0.41) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL25075107 | 0.84 | NPC1 (0.41) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL26494176 | 0.82 | NPC1 (0.47) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL25075103 | 0.82 | HSD11B1 (0.49) | HSD11B1ELANEALDH1A1 | |
| SCHEMBL26494190 | 0.82 | NPC1 (0.41) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL25075451 | 0.82 | GNAI3 (0.46) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL26494075 | 0.82 | NPC1 (0.44) | GNAI3GNAO1GNAI1NPC1HSD11B1 | |
| SCHEMBL25075134 | 0.81 | NPC1 (0.40) | GNAI3GNAO1GNAI1NPC1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |