Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.32 |
| ▸ | CHRNB3 | Q05901 | 2/20 | 0.32 |
| ▸ | CHRNA6 | Q15825 | 2/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26494296 | 0.86 | HRH3 (0.47) | HRH3 | |
| SCHEMBL26494297 | 0.86 | HRH3 (0.36) | LMNAHRH3HSD11B1CHRNB2CHRNA3 | |
| SCHEMBL24671074 | 0.81 | CHRNB2 (0.38) | HTTLMNAHRH3HSD11B1CHRNB2 | |
| SCHEMBL26790076 | 0.80 | HTT (0.46) | HTTLMNAHRH3ALDH1A1HSD11B1 | |
| SCHEMBL26498813 | 0.80 | MEN1 (0.35) | DPP4LMNAHRH3HSD11B1CHRNB2 | |
| SCHEMBL25480236 | 0.79 | CHRNB2 (0.39) | HRH3HSD11B1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL24204376 | 0.78 | HTT (0.43) | HTTDPP4LMNAL3MBTL3L3MBTL1 | |
| SCHEMBL19735106 | 0.76 | PIK3CD (0.37) | HRH3HSD11B1CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL26263657 | 0.76 | HRH3 (0.46) | HRH3 | |
| SCHEMBL24204686 | 0.74 | HTT (0.40) | HTTDPP4LMNAL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |