Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 5/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.33 |
| ▸ | CHRNB3 | Q05901 | 4/20 | 0.33 |
| ▸ | CHRNA6 | Q15825 | 4/20 | 0.33 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24204376 | 0.88 | HTT (0.43) | HTTLMNADPP4CYP1A2TDP1 | |
| SCHEMBL24207501 | 0.83 | CHRNB2 (0.33) | HRH3CHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL27350123 | 0.78 | CYP1A2 (0.41) | HTTLMNADPP4CYP1A2TDP1 | |
| SCHEMBL6840185 | 0.74 | CYP1A2 (0.58) | HTTDPP4CYP1A2TDP1ALDH1A1 | |
| SCHEMBL25075304 | 0.74 | HTT (0.38) | HTTLMNADPP4CYP1A2TDP1 | |
| SCHEMBL26042842 | 0.71 | L3MBTL3 (0.54) | HTTLMNAALDH1A1HRH3L3MBTL3 | |
| SCHEMBL24206985 | 0.71 | HTT (0.49) | HTTLMNAALDH1A1HRH3L3MBTL3 | |
| SCHEMBL24204568 | 0.71 | HTT (0.49) | HTTLMNAALDH1A1HRH3L3MBTL3 | |
| SCHEMBL26748102 | 0.71 | ALDH1A1 (0.36) | ALDH1A1L3MBTL3L3MBTL1 | |
| SCHEMBL19203828 | 0.70 | HTT (0.61) | HTTLMNAALDH1A1HRH3CHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022012623-A1 | DEGRADATION OF (EGFR) BY CONJUGATION OF EGFR INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-01-20 | — | — | WO | disclosed |