Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 7/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.39 |
| ▸ | CHRNB3 | Q05901 | 5/20 | 0.39 |
| ▸ | CHRNA6 | Q15825 | 5/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10119970 | 0.87 | CHRNB2 (0.50) | HTTHRH3CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL22874779 | 0.86 | HTT (0.50) | HTTHRH3LMNACHRNB2CHRNA3 | |
| SCHEMBL25480271 | 0.84 | HRH3 (0.59) | HTTHRH3CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL24671074 | 0.83 | CHRNB2 (0.38) | HTTHRH3LMNACHRNB2CHRNA3 | |
| SCHEMBL19111278 | 0.83 | CHRNB2 (0.53) | HRH3LMNACHRNB2CHRNA3CHRNA4 | |
| SCHEMBL25489062 | 0.81 | HSD11B1 (0.53) | HRH3LMNACHRNB2CHRNA3CHRNA4 | |
| SCHEMBL25075304 | 0.80 | HTT (0.38) | HTTHRH3LMNACHRNB2CHRNA3 | |
| SCHEMBL25581281 | 0.80 | CHRNB2 (0.44) | HTTHRH3CHRNB2CHRNA3CHRNA4 | |
| SCHEMBL13621132 | 0.79 | HTT (0.50) | HTTHRH3LMNACHRNB2CHRNA3 | |
| SCHEMBL12384645 | 0.79 | NAMPT (0.43) | HTTHRH3LMNACHRNB2CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023220134-A1 | PYRAZINE DERIVATIVES AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2023-11-16 | — | — | WO | disclosed |