Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25074975 | 0.94 | HSD11B1 (0.46) | ALDH1A1USP2KDM4EHTTHSD11B1 | |
| SCHEMBL26295698 | 0.88 | ALDH1A1 (0.48) | ALDH1A1USP2KDM4EHSD11B1SMN1; SMN2 | |
| SCHEMBL26295683 | 0.86 | HRH3 (0.50) | ALDH1A1USP2KDM4EHSD11B1SMN1; SMN2 | |
| SCHEMBL17540491 | 0.84 | HPGD (0.47) | ALDH1A1POLBHTTHSD11B1KMT2A | |
| SCHEMBL25565704 | 0.82 | CARM1 (0.50) | POLBHTT | |
| SCHEMBL26295620 | 0.82 | SMN1; SMN2 (0.53) | ALDH1A1KDM4EPOLBHSD11B1KMT2A | |
| SCHEMBL22874779 | 0.81 | HTT (0.50) | ALDH1A1POLBHTTHSD11B1KMT2A | |
| SCHEMBL25075431 | 0.81 | HRH3 (0.48) | ALDH1A1USP2HSD11B1SMN1; SMN2L3MBTL1 | |
| SCHEMBL26501262 | 0.81 | HRH2 (0.44) | ALDH1A1USP2HSD11B1SMN1; SMN2 | |
| SCHEMBL10119952 | 0.81 | HPGD (0.54) | ALDH1A1POLBHTTHSD11B1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023023537-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF BRUTON'S TYROSINE KINASE | ENDOTARGET INC. (US) | 2023-02-23 | — | — | WO | disclosed |