Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.43 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | RPS27 | P42677 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ASPH | Q12797 | 1/20 | 0.37 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.37 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2500326 | 0.90 | PRKACA (0.47) | ADORA1ADORA2ACYP11B1CYP11B2CDK8 | |
| SCHEMBL2505744 | 0.81 | ADORA1 (0.42) | ADORA1ADORA2ACYP11B1CYP11B2 | |
| SCHEMBL1317568 | 0.77 | HRH4 (0.52) | ADORA2ACYP11B1CYP11B2RPS27SMN1; SMN2 | |
| SCHEMBL2521058 | 0.77 | EGLN2 (0.39) | CYP11B1CYP11B2 | |
| SCHEMBL2506224 | 0.76 | PIK3CD (0.46) | ADORA1ADORA2ACYP11B1CYP11B2 | |
| SCHEMBL2507060 | 0.76 | CYP11B2 (0.44) | ADORA1ADORA2ACYP11B1CYP11B2 | |
| SCHEMBL1998196 | 0.69 | KDM4E (0.49) | KDM4EALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL1317062 | 0.68 | SMN1; SMN2 (0.55) | CYP11B1CYP11B2CDK8MAPK1KDM4E | |
| SCHEMBL22784143 | 0.68 | CCNC (0.51) | CCNCCDK8KDM4EALDH1A1MAPT | |
| SCHEMBL29133731 | 0.66 | EGFR (0.63) | CCNCCDK8MAPK1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |