Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | KDM1A | O60341 | 8/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.37 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2500326 | 0.78 | PRKACA (0.47) | CYP11B1CYP11B2 | |
| SCHEMBL2506224 | 0.78 | PIK3CD (0.46) | CYP11B1CYP11B2 | |
| SCHEMBL1317288 | 0.78 | KDM1A (0.42) | EGLN2CYP11B1CYP11B2KDM1A | |
| SCHEMBL2510144 | 0.77 | ADORA1 (0.44) | CYP11B1CYP11B2 | |
| SCHEMBL2507060 | 0.76 | CYP11B2 (0.44) | CYP11B1CYP11B2 | |
| SCHEMBL2505744 | 0.71 | ADORA1 (0.42) | EGLN2CYP11B1CYP11B2 | |
| SCHEMBL2522497 | 0.67 | KDM1A (0.44) | CYP11B1CYP11B2KDM1ATLR9TLR8 | |
| SCHEMBL1318061 | 0.65 | AURKA (0.54) | CYP11B1CYP11B2KDM1A | |
| SCHEMBL1317045 | 0.64 | AURKA (0.55) | CYP11B1CYP11B2KDM1A | |
| SCHEMBL26443908 | 0.64 | KDM1A (0.47) | EGLN2CYP11B1CYP11B2KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2362775-A1 | CHEMICAL COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-09-07 | — | — | EP | disclosed |
| WO-2010059658-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-05-27 | — | — | WO | disclosed |