Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.65 |
| ▸ | GLA | P06280 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 6/20 | 0.65 |
| ▸ | HPGD | P15428 | 5/20 | 0.65 |
| ▸ | PPARG | P37231 | 1/20 | 0.64 |
| ▸ | MAOB | P27338 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | CASP1 | P29466 | 2/20 | 0.53 |
| ▸ | CASP7 | P55210 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.50 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.49 |
| ▸ | CBFB | Q13951 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1711024 | 0.89 | ALDH1A1 (0.76) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL2505053 | 0.88 | ALDH1A1 (0.62) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL2510780 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL1710778 | 0.87 | MAOB (0.67) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL1710937 | 0.87 | ALDH1A1 (0.65) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL17083907 | 0.84 | PPARG (0.70) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL1711220 | 0.84 | PPARG (0.73) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL2508919 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL1711145 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4EGLAGAAHPGD | |
| SCHEMBL1710766 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KDM4EGLAGAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344462-B1 | PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | UNIV DUNDEE (GB) | 2016-05-18 | — | — | EP | disclosed |
| US-8563557-B2 | Pyrimidine derivatives and their pharmaceutical use | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2013-10-22 | — | — | US | disclosed |
| US-20110245282-A1 | Compounds | University Court of the University of Dundee University Court of the University of St. Andrews | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245282-A1 | Compounds | NAT1, AR, ARSA | ALDH1A1 1954/4885KDM4E 3359/4885GLA 1050/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.