Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.73 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.63 |
| ▸ | RAB9A | P51151 | 3/20 | 0.63 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NPC1 | O15118 | 2/20 | 0.63 |
| ▸ | MAOB | P27338 | 2/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | GLA | P06280 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | HPGD | P15428 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ESR1 | P03372 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1710778 | 0.86 | MAOB (0.67) | PPARGKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL1711024 | 0.86 | ALDH1A1 (0.76) | PPARGKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL28471066 | 0.85 | PPARG (1.00) | PPARGKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL1710937 | 0.84 | ALDH1A1 (0.65) | PPARGKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL2510193 | 0.84 | ALDH1A1 (0.65) | PPARGKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL2510780 | 0.84 | ALDH1A1 (0.65) | PPARGKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL1436908 | 0.84 | RAB9A (0.74) | PPARGKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL17083907 | 0.83 | PPARG (0.70) | PPARGKDM4EALDH1A1RAB9ANPC1 | |
| SCHEMBL28469680 | 0.81 | PPARG (0.77) | PPARGKDM4EALDH1A1RAB9APOLB | |
| SCHEMBL2034492 | 0.80 | ALDH1A1 (0.85) | KDM4EALDH1A1RAB9APOLBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344462-B1 | PYRIMIDINE DERIVATIVES AND THEIR PHARMACEUTICAL USE | UNIV DUNDEE (GB) | 2016-05-18 | — | — | EP | disclosed |
| US-8563557-B2 | Pyrimidine derivatives and their pharmaceutical use | UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2013-10-22 | — | — | US | disclosed |
| US-20110245282-A1 | Compounds | University Court of the University of Dundee University Court of the University of St. Andrews | 2011-10-06 | — | — | US | disclosed |
| EP-2344462-A1 | PYRIMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE | The University Court of the University of Dundee (GB) | 2011-07-20 | — | — | EP | disclosed |
| WO-2010038043-A1 | PYRIMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE | THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE (GB) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245282-A1 | Compounds | NAT1, AR, ARSA | PPARG 354/4885KDM4E 3359/4885ALDH1A1 1954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.