Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.69 |
| ▸ | DRD3 | P35462 | 6/20 | 0.69 |
| ▸ | HTR1A | P08908 | 4/20 | 0.69 |
| ▸ | DRD4 | P21917 | 3/20 | 0.69 |
| ▸ | HTR2A | P28223 | 3/20 | 0.69 |
| ▸ | HTR2C | P28335 | 3/20 | 0.69 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.51 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.51 |
| ▸ | NCF1 | P14598 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361520 | 0.85 | DRD2 (0.72) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL28845229 | 0.84 | HTR1A (0.49) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL24683684 | 0.81 | DRD2 (1.00) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL25106971 | 0.81 | DRD2 (0.65) | DRD2DRD3HTR1ADRD4HTR2A | |
| Hydrochloric Acid SCHEMBL11552605 | 0.80 | HTR1A (0.68) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL10424519 | 0.77 | HTR1A (0.59) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL22169146 | 0.77 | DRD2 (0.49) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL19561871 | 0.76 | CHRNA7 (0.49) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL25106668 | 0.75 | DRD2 (0.48) | DRD2DRD3HTR1ADRD4HTR2A | |
| SCHEMBL11557911 | 0.75 | LMNA (0.50) | DRD2DRD3HTR1ADRD4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230076435-A1 | MODIFIER OF FOUR-MEMBERED RING DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF | SHANGHAI HANSOH BIOMEDICAL CO., LTD. (CN) | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230076435-A1 | MODIFIER OF FOUR-MEMBERED RING DERIVATIVE, PREPARATION METHOD AND APPLICATION THEREOF | GRM4, GRM5, GRIA4 | DRD2 343/4885DRD3 367/4885HTR1A 75/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.