Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 3/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25109735 | 0.87 | NCF1 (0.48) | HRH4HRH3SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL25481136 | 0.86 | L3MBTL1 (0.34) | SMN1; SMN2KDM4ETDP1THRBLMNA | |
| SCHEMBL25109733 | 0.86 | NPC1 (0.45) | HRH4HRH3SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL25108926 | 0.82 | NCF1 (0.48) | HRH4HRH3KDM4ETDP1THRB | |
| SCHEMBL22793930 | 0.80 | KDM4E (0.43) | HRH4HRH3SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL22793929 | 0.79 | KDM4E (0.42) | HRH4HRH3SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL25109776 | 0.79 | HRH3 (0.46) | HRH4HRH3SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL25111056 | 0.78 | KDM4E (0.37) | HRH4HRH3SMN1; SMN2KDM4ETDP1 | |
| SCHEMBL25109011 | 0.77 | HRH3 (0.40) | HRH3KDM4ES1PR1GAAMEN1 | |
| SCHEMBL25111079 | 0.77 | HRH3 (0.38) | HRH3KDM4ES1PR1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230072658-A1 | SMARCA DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-03-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230072658-A1 | SMARCA DEGRADERS AND USES THEREOF | SMARCA1, SMARCB1, SMARCE1 | HRH4 3193/4885HRH3 1490/4885SMN1; SMN2 832/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.