SCHEMBL25111998

SCHEMBL25111998

Nc1nn(C2CC2)cc1Br

nearest known ligand 0.31

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
AADAT Q8N5Z0 1/20 0.31
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
KMT2A Q03164 1/20 0.30
ADORA2A P29274 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24248063 0.77 LRRK2 (0.30)
SCHEMBL25112225 0.77 LRRK2 (0.34)
SCHEMBL20689124 0.75 KDM5A (0.42)
SCHEMBL22532828 0.73 CTSD (0.45) KDM4E
SCHEMBL12427508 0.71 AADAT (0.37) AADATALDH1A1ADORA2A
SCHEMBL31729323 0.71 PDE4D (0.32)
SCHEMBL25337033 0.69 EPHX2 (0.37) AADATKDM4EALDH1A1
SCHEMBL27737569 0.69 BTK (0.39) AADATKDM4EALDH1A1KMT2A
SCHEMBL28047375 0.69 ADORA2A (0.37) AADATKDM4EALDH1A1KMT2AADORA2A
SCHEMBL31078355 0.68 AADAT (0.36) AADATADORA2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023036140-A1 3CLPRO PROTEASE INHIBITOR 上海齐鲁制药研究中心有限公司 2023-03-16 WO disclosed