Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.54 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.54 |
| ▸ | FER | P16591 | 1/20 | 0.54 |
| ▸ | LTK | P29376 | 1/20 | 0.54 |
| ▸ | CDK8 | P49336 | 1/20 | 0.54 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ROS1 | P08922 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12683716 | 0.95 | ALDH1A1 (0.59) | ALDH1A1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL2643929 | 0.95 | — | — | |
| SCHEMBL8230577 | 0.83 | CHEK1 (0.66) | ALDH1A1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL11878147 | 0.83 | CHEK1 (0.66) | ALDH1A1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL8889856 | 0.83 | CSNK1G1 (0.66) | ALDH1A1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL3077372 | 0.80 | ALDH1A1 (0.50) | ALDH1A1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL11878670 | 0.79 | MAPT (0.49) | ALDH1A1LRRK2KDM4ECSNK1G1CHEK1 | |
| SCHEMBL11880410 | 0.79 | NOX1 (0.49) | ALDH1A1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL11877335 | 0.79 | CSNK1G1 (0.42) | ALDH1A1ACVR1LRRK2PDGFRAFER | |
| SCHEMBL8890624 | 0.79 | MAPT (0.49) | ALDH1A1LRRK2KDM4ECSNK1G1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541407-B2 | Substituted benzo-pyrido-triazolo-diazepine compounds | ARQULE, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| US-8541407-B2 | Substituted benzo-pyrido-triazolo-diazepine compounds | ARQULE, INC. (US) | 2013-09-24 | — | — | US | disclosed |
| WO-2011123678-A2 | SUBSTITUTED BENZO-PYRIDO-TRIAZOLO-DIAZEPINE COMPOUNDS | ARQULE, INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011123678-A2 | SUBSTITUTED BENZO-PYRIDO-TRIAZOLO-DIAZEPINE COMPOUNDS | ARQULE, INC. (US) | 2011-10-06 | — | — | WO | disclosed |
| US-20110245236-A1 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds | ARQULE, INC. (US) | 2011-10-06 | — | — | US | disclosed |
| US-20110245236-A1 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds | ARQULE, INC. (US) | 2011-10-06 | — | — | US | disclosed |
| WO-1997000252-A1 | TRICYCLIC INHIBITORS OF PROTEIN FARNESYLTRANSFERASE | WARNER-LAMBERT COMPANY (US) | 1997-01-03 | — | — | WO | disclosed |
| US-3956297-A | 9H-Dibenzo[b,f]imidazo[1,2-d][1,4]diazepines | THE UPJOHN COMPANY (US) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110245236-A1 | Substituted Benzo-Pyrido-Triazolo-Diazepine Compounds | BRD4, PDXK, THPO | ALDH1A1 1709/4885ACVR1 3447/4885LRRK2 2277/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.