SCHEMBL25112970

SCHEMBL25112970

CC(C)(O)C(F)(F)c1cccc(CN)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 1/20 0.46
MAOB P27338 1/20 0.44
ENPP2 Q13822 1/20 0.44
NOS1 P29475 4/20 0.44
NOS2 P35228 4/20 0.44
ALDH1A1 P00352 2/20 0.44
NOS3 P29474 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
CYP3A4 P08684 1/20 0.44
NFKB1 P19838 1/20 0.44
HTR2A P28223 1/20 0.44
HTR2C P28335 1/20 0.44
HTR2B P41595 1/20 0.44
KIF11 P52732 1/20 0.43
IDO1 P14902 2/20 0.41
PNMT P11086 1/20 0.40
LOXL2 Q9Y4K0 3/20 0.40
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
ACP3 P15309 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1908518 0.82 ENPP2 (0.50) TAAR1MAOBENPP2NOS1NOS2
SCHEMBL12024583 0.82 TAAR1 (0.52) TAAR1MAOBENPP2NOS1NOS2
SCHEMBL2089239 0.82 TAAR1 (0.52) TAAR1MAOBENPP2NOS1NOS2
SCHEMBL27317288 0.80 ENPP2 (0.48) TAAR1MAOBENPP2NOS1NOS2
SCHEMBL8097447 0.79 TAAR1 (0.49) TAAR1MAOBENPP2NOS1NOS2
SCHEMBL27870376 0.79 TAAR1 (0.49) TAAR1MAOBENPP2NOS1NOS2
SCHEMBL507652 0.77 KIF11 (0.50) TAAR1MAOBENPP2NOS1NOS2
SCHEMBL29463258 0.77 TAAR1 (0.71) TAAR1MAOBALDH1A1HTR2AHTR2C
SCHEMBL39655 0.77 TAAR1 (0.71) TAAR1MAOBALDH1A1HTR2AHTR2C
SCHEMBL29755008 0.77 KIF11 (0.50) TAAR1MAOBENPP2NOS1NOS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4148056-A1 SOS1 INHIBITOR CONTAINING PHOSPHORUS CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD. (CN) 2023-03-15 EP disclosed