Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 5/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | ACLY | P53396 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3134786 | 0.97 | TP53 (0.50) | MAPTTP53PSMB5PKMACLY | |
| SCHEMBL3149386 | 0.78 | PSMB5 (0.72) | PSMB5 | |
| SCHEMBL19381927 | 0.74 | MEN1 (0.54) | MAPTTP53PSMB5LMNATHRB | |
| SCHEMBL3149025 | 0.71 | PSMB5 (0.51) | PSMB5 | |
| SCHEMBL15195208 | 0.70 | MMP2 (0.48) | MAPTPSMB5ALDH1A1 | |
| SCHEMBL2509714 | 0.70 | ALDH1A1 (0.43) | TP53PSMB5LMNAALDH1A1POLB | |
| SCHEMBL19387845 | 0.70 | PSMB5 (0.70) | PSMB5 | |
| SCHEMBL2506921 | 0.69 | PSMB5 (0.53) | PSMB5 | |
| SCHEMBL2512511 | 0.69 | PSMB5 (0.47) | PSMB5POLB | |
| SCHEMBL2506651 | 0.69 | MEN1 (0.50) | MAPTTP53PSMB5PKMLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552216-B1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARM INC (US) | 2018-01-24 | — | — | EP | claimed |
| EP-2552216-B1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARM INC (US) | 2018-01-24 | — | — | EP | disclosed |
| EP-2552216-B1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARM INC (US) | 2018-01-24 | — | — | EP | disclosed |
| US-9023832-B2 | Derivatives of 1-amino-2-cyclopropylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-05-05 | — | — | US | disclosed |
| US-20140179631-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-06-26 | — | — | US | disclosed |
| US-20140011998-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-01-09 | — | — | US | disclosed |
| US-8513218-B2 | Derivatives of 1-amino-2-cyclopropylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| US-8513218-B2 | Derivatives of 1-amino-2-cyclopropylethylboronic acid | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| WO-2011123502-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC (US) | 2011-10-06 | — | — | WO | disclosed |
| US-20110245203-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-10-06 | — | — | US | disclosed |
| US-20110245203-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2011-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179631-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | MAPT 1066/4885TP53 787/4885PSMB5 2/4885 |
| US-20140011998-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | MAPT 1066/4885TP53 787/4885PSMB5 2/4885 |
| US-20110245203-A1 | DERIVATIVES OF 1-AMINO-2-CYCLOPROPYLETHYLBORONIC ACID | PSMB6, PSMB5, PSMB1 | MAPT 1066/4885TP53 787/4885PSMB5 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.