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SCHEMBL2511657

SCHEMBL2511657

CS(=O)(=O)N1CCN(c2ccc(OC3CN(Cc4cccc(C(F)(F)F)c4)C3)cn2)CC1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ S1PR1 P21453 2/20 0.42
▸ S1PR5 Q9H228 2/20 0.42
▸ PDGFRA P16234 1/20 0.42
▸ GPR119 Q8TDV5 1/20 0.42
▸ FFAR1 O14842 1/20 0.41
▸ PRKAA2 P54646 1/20 0.41
▸ PPARG P37231 1/20 0.40
▸ NR1H2 P55055 1/20 0.40
▸ NR1H3 Q13133 1/20 0.40
▸ KDM4E B2RXH2 3/20 0.40
▸ CNR2 P34972 3/20 0.40
▸ ALDH1A1 P00352 2/20 0.40
▸ SCN9A Q15858 1/20 0.40
▸ GAA P10253 1/20 0.40
▸ TEAD1 P28347 2/20 0.40
▸ LMNA P02545 2/20 0.39
▸ PRKD3 O94806 1/20 0.39
▸ CDK7 P50613 1/20 0.39
▸ JAK3 P52333 1/20 0.39
▸ TNK2 Q07912 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1670031 0.89 KDM4E (0.51) GPR119PRKAA2PPARGKDM4EALDH1A1
SCHEMBL2508495 0.84 CHRM2 (0.44) GPR119PRKAA2NR1H2NR1H3KDM4E
SCHEMBL15368999 0.83 GPR119 (0.46) GPR119PRKAA2KDM4EALDH1A1
SCHEMBL1668287 0.82 GPR119 (0.46) S1PR5GPR119PPARGALDH1A1LMNA
SCHEMBL1670864 0.82 GPR119 (0.46) GPR119PRKAA2ALDH1A1LMNASMN1; SMN2
SCHEMBL1668753 0.82 GPR119 (0.46) GPR119GAASMN1; SMN2
SCHEMBL1668953 0.81 GPR119 (0.47) GPR119PRKAA2NR1H2NR1H3
SCHEMBL1668252 0.79 GPR119 (0.49) GPR119
SCHEMBL1668996 0.79 GPR119 (0.50) GPR119PRKAA2KDM4E
SCHEMBL1668232 0.78 KDM4E (0.53) GPR119PRKAA2PPARGKDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8575168-B2 Compounds and compositions as modulators of GPR119 activity IRM LLC (BM) 2013-11-05 — — US claimed
US-20110245220-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2011-10-06 — — US claimed
US-8575168-B2 Compounds and compositions as modulators of GPR119 activity IRM LLC (BM) 2013-11-05 — — US disclosed
US-8575168-B2 Compounds and compositions as modulators of GPR119 activity IRM LLC (BM) 2013-11-05 — — US disclosed
US-8575168-B2 Compounds and compositions as modulators of GPR119 activity IRM LLC (BM) 2013-11-05 — — US disclosed
US-20110245220-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2011-10-06 — — US disclosed
US-20110245220-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2011-10-06 — — US disclosed
US-20110245220-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2011-10-06 — — US disclosed
WO-2011044001-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY IRM LLC (BM) 2011-04-14 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110245220-A1 COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY GPR119, GPR65, GPR39 S1PR1 598/4885S1PR5 606/4885PDGFRA 405/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.