SCHEMBL251422

SCHEMBL251422

C=Cc1ccc(O)c(-n2nc3ccccc3n2)c1

nearest known ligand 0.61

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.61
RAB9A P51151 3/20 0.61
LMNA P02545 1/20 0.61
TRPA1 O75762 1/20 0.41
MEN1 O00255 4/20 0.39
KMT2A Q03164 4/20 0.39
POLB P06746 4/20 0.38
KDM4E B2RXH2 3/20 0.37
HPGD P15428 1/20 0.37
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
TSHR P16473 1/20 0.33
KCNMA1 Q12791 1/20 0.33
GAA P10253 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL6571740 0.91 NPC1 (0.56) NPC1RAB9ALMNATRPA1MEN1
SCHEMBL9868391 0.89 NPC1 (0.47) NPC1RAB9ALMNATRPA1MEN1
SCHEMBL7921927 0.84 NPC1 (0.46) NPC1RAB9ALMNATRPA1MEN1
SCHEMBL14126172 0.83 NPC1 (0.66) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL10728649 0.83 RAB9A (0.61) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL14017581 0.83 NPC1 (0.43) NPC1RAB9ALMNATRPA1MEN1
SCHEMBL10547324 0.82 NPC1 (0.64) NPC1RAB9ALMNATRPA1MEN1
SCHEMBL28696120 0.81 NPC1 (0.62) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL7170091 0.80 NPC1 (0.54) NPC1RAB9ALMNAMEN1KMT2A
SCHEMBL29046137 0.79 NPC1 (0.65) NPC1RAB9ALMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 839 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12595368-B2 UV/HEVL-filtering contact lenses ALCON INC. (CH) 2026-04-07 US claimed
EP-4713720-A2 HIGH-ENERGY-VIOLET-ABSORBING VINYLIC MONOMERS Alcon Inc. (CH) 2026-03-25 EP claimed
EP-4713721-A1 UV/HEVL-FILTERING SILICONE HYDROGEL CONTACT LENSES Alcon Inc. (CH) 2026-03-25 EP claimed
US-20250223392-A1 HYDROPHILIZED POLYDIORGANOSILOXANE VINYLIC CROSSLINKERS AND USES THEREOF ALCON INC (CH) 2025-07-10 US claimed
US-12286501-B2 Hydrophilized polydiorganosiloxane vinylic crosslinkers and uses thereof ALCON INC. (CH) 2025-04-29 US claimed
EP-4529621-A1 UV/HEVL-FILTERING CONTACT LENSES Alcon Inc. (CH) 2025-04-02 EP claimed
WO-2025032504-A2 UV/HEVL-FILTERING SILICONE HYDROGEL CONTACT LENSES ALCON INC. (CH) 2025-02-13 WO claimed
US-20250052927-A1 UV/HEVL-FILTERING SILICONE HYDROGEL CONTACT LENSES ALCON INC (CH) 2025-02-13 US claimed
CN-119137510-A UV/HEVL filtering contact lenses 爱尔康公司 2024-12-13 CN claimed
US-20240392055-A1 UV/HEVL-FILTERING SILICONE HYDROGEL CONTACT LENSES ALCON INC (CH) 2024-11-28 US claimed
WO-2010133680-A1 ACTINICALLY-CROSSLINKABLE SILOXANE-CONTAINING COPOLYMERS NOVARTIS AG (CH) 2010-11-25 WO claimed
US-5980851-A Transparent electrically conductive plate NIPPON OIL, CO., LTD. (JP) 1999-11-09 US claimed
US-5770314-A Transparent electrically conductive plate NIPPON OIL CO., LTD. (JP) 1998-06-23 US claimed
US-5382633-A Modified polymers 3I RESEARCH EXPLOITATION LIMITED (GB) 1995-01-17 US claimed
US-5002979-A Hyydrogenorganosilicon monomer, organosilicon, fluoroorgano monomer, a hydrophobic monomer and a crosslinking agent BAUSCH & LOMB INCORPORATED (US) 1991-03-26 US claimed
EP-0211067-B1 OXYGEN-PERMEABLE LENSES Bausch & Lomb Incorporated (US) 1991-03-13 EP claimed
EP-0211067-A1 OXYGEN-PERMEABLE LENSES. BAUSCH & LOMB (US) 1987-02-25 EP claimed
EP-0209597-A1 EXTENDED-WEAR LENSES Bausch & Lomb Incorporated (US) 1987-01-28 EP claimed
WO-1986004342-A1 OXYGEN-PERMEABLE LENSES BAUSCH AND LOMB INCORPORATED (US) 1986-07-31 WO claimed
WO-1986004343-A1 EXTENDED-WEAR LENSES BAUSCH AND LOMB INCORPORATED (US) 1986-07-31 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12595368-B2 UV/HEVL-filtering contact lenses UACA, HSPA4L, RAD54L NPC1 3998/4885RAB9A 4835/4885LMNA 2948/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.