Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28343653 | 0.87 | KDM4E (0.60) | LMNAALDH1A1KDM4ESIRT1MEN1 | |
| Hydrochloric Acid SCHEMBL6580775 | 0.85 | KDM4E (0.59) | LMNAALDH1A1KDM4ESIRT1MEN1 | |
| SCHEMBL10210904 | 0.85 | KDM4E (0.63) | LMNAALDH1A1KDM4ESIRT1MEN1 | |
| SCHEMBL6585398 | 0.84 | HDAC3 (0.56) | LMNAALDH1A1KDM4ESIRT1MEN1 | |
| SCHEMBL29194341 | 0.84 | LMNA (0.49) | LMNAKDM4ECHRM3MEN1KMT2A | |
| SCHEMBL20424672 | 0.83 | LMNA (0.54) | LMNACHRM3SIGMAR1 | |
| SCHEMBL5216465 | 0.83 | HCRTR1 (0.60) | LMNAALDH1A1SIRT1 | |
| SCHEMBL9616882 | 0.83 | KMT2A (0.65) | LMNAALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL27416833 | 0.82 | LMNA (0.55) | LMNAALDH1A1KDM4ESIGMAR1 | |
| SCHEMBL28129042 | 0.81 | HCRTR1 (0.56) | LMNACHRM3OPRD1CYP1A2CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062049-A1 | HETEROCYCLIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2023-04-20 | — | — | WO | disclosed |