Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.43 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.39 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365211 | 1.00 | CD274 (0.43) | CD274PDCD1BRD4PTGER1XDH | |
| SCHEMBL30364692 | 0.92 | CD274 (0.51) | CD274PDCD1BRD4RIPK1DHFR | |
| SCHEMBL25149474 | 0.92 | CD274 (0.51) | CD274PDCD1BRD4RIPK1DHFR | |
| SCHEMBL25149505 | 0.91 | IRAK4 (0.46) | CD274PDCD1BRD4DHFRDCPS | |
| SCHEMBL25149242 | 0.90 | PTGER1 (0.44) | CD274PDCD1PTGER1RIPK1POLB | |
| SCHEMBL30364967 | 0.90 | PTGER1 (0.44) | CD274PDCD1PTGER1RIPK1POLB | |
| SCHEMBL30365021 | 0.82 | CD274 (0.52) | CD274PDCD1PTGER1RIPK1PDCD1LG2 | |
| SCHEMBL25149355 | 0.82 | CD274 (0.52) | CD274PDCD1PTGER1RIPK1PDCD1LG2 | |
| SCHEMBL30364797 | 0.82 | CD274 (0.52) | CD274PDCD1PTGER1RIPK1PDCD1LG2 | |
| SCHEMBL25149477 | 0.81 | BRD4 (0.39) | CD274PDCD1BRD4RIPK1GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |