Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.52 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 6/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.40 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.40 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.40 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.40 |
| ▸ | PDCD1LG2 | Q9BQ51 | 2/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365021 | 1.00 | CD274 (0.52) | CD274PDCD1ALDH1A1TSHRCNR1 | |
| SCHEMBL30364797 | 1.00 | CD274 (0.52) | CD274PDCD1ALDH1A1TSHRCNR1 | |
| SCHEMBL30364692 | 0.91 | CD274 (0.51) | CD274PDCD1CNR1RIPK1CNR2 | |
| SCHEMBL25149474 | 0.91 | CD274 (0.51) | CD274PDCD1CNR1RIPK1CNR2 | |
| SCHEMBL30364967 | 0.91 | PTGER1 (0.44) | CD274PDCD1CNR1RIPK1PTGER1 | |
| SCHEMBL25149242 | 0.91 | PTGER1 (0.44) | CD274PDCD1CNR1RIPK1PTGER1 | |
| SCHEMBL25148658 | 0.82 | CD274 (0.43) | CD274PDCD1RIPK1PTGER1PDCD1LG2 | |
| SCHEMBL30365211 | 0.82 | CD274 (0.43) | CD274PDCD1RIPK1PTGER1PDCD1LG2 | |
| SCHEMBL25149505 | 0.82 | IRAK4 (0.46) | CD274PDCD1PARP15PARP10PDCD1LG2 | |
| SCHEMBL25149261 | 0.81 | MEN1 (0.39) | CD274PDCD1CNR1RIPK1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |