Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 6/20 | 0.51 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | VDR | P11473 | 1/20 | 0.41 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.39 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | PDCD1LG2 | Q9BQ51 | 3/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25149474 | 1.00 | CD274 (0.51) | CD274PDCD1BRD4VDRGRM4 | |
| SCHEMBL25148658 | 0.92 | CD274 (0.43) | CD274PDCD1BRD4GRM4RIPK1 | |
| SCHEMBL30365211 | 0.92 | CD274 (0.43) | CD274PDCD1BRD4GRM4RIPK1 | |
| SCHEMBL25149505 | 0.91 | IRAK4 (0.46) | CD274PDCD1BRD4GRM4DHFR | |
| SCHEMBL25149355 | 0.91 | CD274 (0.52) | CD274PDCD1VDRCNR1CNR2 | |
| SCHEMBL30364797 | 0.91 | CD274 (0.52) | CD274PDCD1VDRCNR1CNR2 | |
| SCHEMBL30365021 | 0.91 | CD274 (0.52) | CD274PDCD1VDRCNR1CNR2 | |
| SCHEMBL30364863 | 0.83 | BRD4 (0.39) | CD274PDCD1BRD4GRM4CNR1 | |
| SCHEMBL25149477 | 0.83 | BRD4 (0.39) | CD274PDCD1BRD4GRM4CNR1 | |
| SCHEMBL22262327 | 0.82 | ALDH1A1 (0.52) | BRD4VDRCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |