Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 8/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 6/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30364863 | 1.00 | BRD4 (0.39) | BRD4MEN1LMNAKMT2ACD274 | |
| SCHEMBL30365050 | 0.92 | MEN1 (0.39) | MEN1LMNAKMT2ACD274PDCD1 | |
| SCHEMBL25149261 | 0.92 | MEN1 (0.39) | MEN1LMNAKMT2ACD274PDCD1 | |
| SCHEMBL30364692 | 0.83 | CD274 (0.51) | BRD4CD274PDCD1PDCD1LG2GRM4 | |
| SCHEMBL25149474 | 0.83 | CD274 (0.51) | BRD4CD274PDCD1PDCD1LG2GRM4 | |
| SCHEMBL25148658 | 0.81 | CD274 (0.43) | BRD4CD274PDCD1PDCD1LG2GRM4 | |
| SCHEMBL30365211 | 0.81 | CD274 (0.43) | BRD4CD274PDCD1PDCD1LG2GRM4 | |
| SCHEMBL25149505 | 0.80 | IRAK4 (0.46) | BRD4CD274PDCD1PDCD1LG2GRM4 | |
| SCHEMBL25149548 | 0.80 | MEN1 (0.40) | BRD4MEN1LMNAKMT2AGRM4 | |
| SCHEMBL31547501 | 0.78 | LMNA (0.42) | MEN1LMNAKMT2APDE4BJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |