Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.39 |
| ▸ | IDH1 | O75874 | 4/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | GUCY1B2 | O75343 | 2/20 | 0.36 |
| ▸ | GUCY1A2 | P33402 | 2/20 | 0.36 |
| ▸ | GUCY1A1 | Q02108 | 2/20 | 0.36 |
| ▸ | GUCY1B1 | Q02153 | 2/20 | 0.36 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30365050 | 1.00 | MEN1 (0.39) | MEN1LMNAKMT2ARIPK1IDH1 | |
| SCHEMBL30364863 | 0.92 | BRD4 (0.39) | MEN1LMNAKMT2ARIPK1CD274 | |
| SCHEMBL25149477 | 0.92 | BRD4 (0.39) | MEN1LMNAKMT2ARIPK1CD274 | |
| SCHEMBL30364797 | 0.81 | CD274 (0.52) | RIPK1PTGER1CD274PDCD1FAAH | |
| SCHEMBL30365021 | 0.81 | CD274 (0.52) | RIPK1PTGER1CD274PDCD1FAAH | |
| SCHEMBL25149355 | 0.81 | CD274 (0.52) | RIPK1PTGER1CD274PDCD1FAAH | |
| SCHEMBL25149242 | 0.80 | PTGER1 (0.44) | RIPK1PTGER1CD274PDCD1FAAH | |
| SCHEMBL30364967 | 0.80 | PTGER1 (0.44) | RIPK1PTGER1CD274PDCD1FAAH | |
| SCHEMBL30364997 | 0.78 | LMNA (0.44) | MEN1LMNAKMT2ACNR1CNR2 | |
| SCHEMBL30364609 | 0.73 | LMNA (0.41) | MEN1LMNAKMT2ACD274CNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023062575-A1 | CYCLIC VINYL SULFONE COMPOUNDS AS WRN INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2023-04-20 | — | — | WO | disclosed |