Citric Acid

SCHEMBL2515258

CC(O)C(=O)O.CC(O)C(=O)O.Cl.Cl.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)CC(O)(CC(=O)O)C(=O)O.O=C(O)O.O=C(O)O.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=C(O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.O=P(O)(O)O.O=P(O)(O)O.O=S(=O)(O)O.O=S(=O)(O)O.[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[O-2].[O-2]

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACVR1 ADORA1 ADORA2A ADORA2B ADORA3 ESR1 ESR2 FLT3 GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B GSC1 HRH1 HTR7 IDH1 IDH2 IRAK1 JAK1 JAK2 JAK3 MEN1 OPRM1 P2RX3 PDE5A SCN10A SCN11A SCN1A SCN2A SCN3A SCN4A SCN5A SCN7A SCN8A SCN9A SIGMAR1 SLC6A2 SYK TACR1 TOP2A TYK2

The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	PDE4A	P27815	1/20	0.42

▸	ALDH1A1	P00352	1/20	0.33

▸	LMNA	P02545	1/20	0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Citric Acid SCHEMBL2518499	0.88	PDE4A (0.51)	PDE4AALDH1A1LMNA
Gluconic Acid SCHEMBL28829555	0.86	PDE4A (0.54)	PDE4AALDH1A1LMNA
Gluconic Acid SCHEMBL27650807	0.86	PDE4A (0.58)	PDE4AALDH1A1LMNA
Gluconic Acid SCHEMBL20876306	0.86	PDE4A (0.58)	PDE4AALDH1A1LMNA
Citric Acid SCHEMBL301655	0.86	PDE4A (0.58)	PDE4AALDH1A1LMNA
Gluconic Acid SCHEMBL27097002	0.84	PDE4A (0.56)	PDE4AALDH1A1LMNA
Citric Acid SCHEMBL301849	0.84	PDE4A (0.56)	PDE4AALDH1A1LMNA
Citric Acid SCHEMBL17513691	0.80	PDE4A (0.58)	PDE4AALDH1A1LMNA
Citric Acid SCHEMBL10802994	0.80	PDE4A (0.61)	PDE4AALDH1A1LMNA
Gluconic Acid SCHEMBL28106011	0.80	PDE4A (0.66)	PDE4AALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20110250270-A1	Compositions containing a capillary-active system with application-relevant diffferentiability and their use	MERZ PHARMA GMBH & CO. KGAA (DE)	2011-10-13	—	—	US	disclosed
US-20080317856-A1	Compositions Containing A Capillary -Active System With Application -Relevant Differentiability, And The Use Thereof	MERZ PHARMA GMBH & CO. KGAA (DE)	2008-12-25	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20080317856-A1	Compositions Containing A Capillary -Active System With Application -Relevant Differentiability, And The Use Thereof	LIPG, FABP2, CPT1B	PDE4A 634/4885ALDH1A1 1691/4885LMNA 1503/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.