Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.35 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SLC13A5 | Q86YT5 | 2/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Gluconic Acid SCHEMBL28829555 | 0.94 | PDE4A (0.54) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL301655 | 0.94 | PDE4A (0.58) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL20876306 | 0.94 | PDE4A (0.58) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL27097002 | 0.93 | PDE4A (0.56) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL301849 | 0.93 | PDE4A (0.56) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL17513691 | 0.89 | PDE4A (0.58) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL10802994 | 0.89 | PDE4A (0.61) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Gluconic Acid SCHEMBL28106011 | 0.89 | PDE4A (0.66) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL3021271 | 0.89 | PDE4A (0.66) | PDE4AALDH1A1LMNAUSP2SLCO1B1 | |
| Citric Acid SCHEMBL2515258 | 0.88 | PDE4A (0.42) | PDE4AALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110250270-A1 | Compositions containing a capillary-active system with application-relevant diffferentiability and their use | MERZ PHARMA GMBH & CO. KGAA (DE) | 2011-10-13 | — | — | US | disclosed |
| US-20080317856-A1 | Compositions Containing A Capillary -Active System With Application -Relevant Differentiability, And The Use Thereof | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080317856-A1 | Compositions Containing A Capillary -Active System With Application -Relevant Differentiability, And The Use Thereof | LIPG, FABP2, CPT1B | PDE4A 634/4885ALDH1A1 1691/4885LMNA 1503/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.