Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.75 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.59 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.59 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.56 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TTR | P02766 | 2/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenclofenac SCHEMBL28279765 | 1.00 | CHRM1 (1.00) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenclofenac SCHEMBL29438086 | 1.00 | CHRM1 (1.00) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenclofenac SCHEMBL30509659 | 1.00 | CHRM1 (1.00) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenclofenac SCHEMBL9692633 | 0.99 | CHRM1 (0.97) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL8165686 | 0.89 | CHRM1 (0.81) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL12608893 | 0.87 | CHRM1 (0.77) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL11089474 | 0.86 | CHRM1 (0.76) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Diclofenac SCHEMBL10779466 | 0.86 | CHRM1 (0.74) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenbufen SCHEMBL1262211 | 0.85 | CHRM1 (0.72) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL4090952 | 0.85 | CHRM1 (0.73) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 13905 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260000741-A1 | METHOD OF AMELIORATING A PRO-INFLAMMATORY IMMUNOPHENOTYPE IN FARBER DISEASE SUBJECTS BY REPEATED ADMINISTRATION OF A RECOMBINANT HUMAN ACID CERAMIDASE | ACERAGEN INC (US) | 2026-01-01 | — | — | US | claimed |
| EP-4628080-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DRUG-RELATED PEPTIC ULCER COMPRISING ZASTAPRAZAN OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Jeil Pharmaceutical Co., Ltd. (KR) | 2025-10-08 | — | — | EP | claimed |
| US-20250025435-A1 | CO-CRYSTALS OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | DOMPE' FARMACEUTICI SPA (IT) | 2025-01-23 | — | — | US | claimed |
| US-12161726-B2 | Biomimetic vesicles and uses thereof | OHIO STATE INNOVATION FOUNDATION (US) | 2024-12-10 | — | — | US | claimed |
| US-RE50218-E1 | Non-steroidal anti-inflammatory ophthalmic compositions | SUN PHARMACEUTICAL INDUSTRIES LIMITED (IN) | 2024-11-26 | — | — | US | claimed |
| EP-4442241-A2 | RETINOL REPLACEMENT IN SKIN TREATMENT | Symrise AG (DE) | 2024-10-09 | — | — | EP | claimed |
| US-20240299348-A1 | MODULATORS OF TRPML, THEIR COMPOSITIONS AND METHODS OF USE | CARAWAY THERAPEUTICS, INC. | 2024-09-12 | — | — | US | claimed |
| EP-4423057-A1 | CO-CRYSTALS OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS, LYSINE AND GABAPENTIN, PHARMACEUTICAL COMPOSITIONS AND THEIR MEDICAL USE | Dompe' Farmaceutici SpA (IT) | 2024-09-04 | — | — | EP | claimed |
| CN-118512401-A | Lipid vesicle compositions with permeation enhancers | 迪迪艾斯研究公司 | 2024-08-20 | — | — | CN | claimed |
| EP-3773445-B1 | RETINOL REPLACEMENT IN SKIN TREATMENT | SYMRISE AG (DE) | 2024-07-24 | — | — | EP | claimed |
| EP-0057047-B1 | PROCESS FOR THE PREPARATION OF 2-(2,4-DICHLOROPHENOXY) PHENYLACETIC ACID | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1984-08-08 | — | — | EP | claimed |
| WO-1984000490-A1 | IMPROVED ANALGESIC AND ANTI-INFLAMMATORY COMPOSITIONS COMPRISING CAFFEINE AND METHODS OF USING SAME | SUNSHINE ABRAHAM | 1984-02-16 | — | — | WO | claimed |
| US-4430510-A | Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid | SCHERING CORPORATION (US) | 1984-02-07 | — | — | US | claimed |
| US-4404396-A | Process for the preparation of 2-(2,4-dichlorophenoxy)-phenylacetic acid | RECKITT & COLMAN PRODUCTS LIMITED (GB) | 1983-09-13 | — | — | US | claimed |
| EP-0078477-A2 | Fenclofenac as TBP blocking agent in iodothyronine immunoassays | MILES LABORATORIES, INC. (US) | 1983-05-11 | — | — | EP | claimed |
| EP-0068222-A1 | Process for the preparation of 2-(2,4-dichlorophenoxy)phenylacetic acid | Technobiotic Ltd. (CH) | 1983-01-05 | — | — | EP | claimed |
| EP-0057047-A1 | Process for the preparation of 2-(2,4-dichlorophenoxy) phenylacetic acid | RECKITT AND COLMAN PRODUCTS LIMITED (GB) | 1982-08-04 | — | — | EP | claimed |
| EP-0051278-A1 | Soft tertiary amine esters of bio-affecting carboxylic acids, processes for preparing and a pharmaceutical composition containing the same | MERCK & CO. INC. (US) | 1982-05-12 | — | — | EP | claimed |
| EP-0039051-A2 | Mannich-base hydroxamic acid prodrugs for the improved bioavailability of non-steroidal anti-inflammatory agents, a process for preparing and a pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1981-11-04 | — | — | EP | claimed |
| US-4279926-A | PHENYL ALKANOIC ACID SALT OF AN AMINO ACID | SPA-SOCIETA PRODOTTI ANTIBIOTICI S.P.A. (IT) | 1981-07-21 | — | — | US | claimed |