Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fenclofenac. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.97 |
| ▸ | CXCL8 | P10145 | 3/20 | 0.73 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.59 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.58 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.54 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenclofenac SCHEMBL25161 | 0.99 | CHRM1 (1.00) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenclofenac SCHEMBL28279765 | 0.99 | CHRM1 (1.00) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenclofenac SCHEMBL30509659 | 0.99 | CHRM1 (1.00) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenclofenac SCHEMBL29438086 | 0.99 | CHRM1 (1.00) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL8165686 | 0.88 | CHRM1 (0.81) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL12608893 | 0.86 | CHRM1 (0.77) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL11089474 | 0.85 | CHRM1 (0.76) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Diclofenac SCHEMBL10779466 | 0.85 | CHRM1 (0.74) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| Fenbufen SCHEMBL1262211 | 0.84 | CHRM1 (0.72) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 | |
| SCHEMBL4090952 | 0.83 | CHRM1 (0.73) | CHRM1CXCL8CAMK2ASLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5173287-A | Carboxylic acid compositions | WYETH | 1992-12-22 | — | — | US | disclosed |
| EP-0078477-B1 | FENCLOFENAC AS TBP BLOCKING AGENT IN IODOTHYRONINE IMMUNOASSAYS | MILES LABORATORIES, INC. (US) | 1986-09-10 | — | — | EP | disclosed |
| US-4468469-A | Substituted phenylacetic acids and salts as TBP blocking agents in iodothyronine immunoassays | MILES LABORATORIES, INC. (US) | 1984-08-28 | — | — | US | disclosed |
| EP-0078477-A2 | Fenclofenac as TBP blocking agent in iodothyronine immunoassays | MILES LABORATORIES, INC. (US) | 1983-05-11 | — | — | EP | disclosed |