Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 1/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.61 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 1/20 | 0.51 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.50 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fenclofenac SCHEMBL28279765 | 0.85 | CHRM1 (1.00) | CHRM1SLC6A2SLC6A4SLC6A3CXCL8 | |
| Fenclofenac SCHEMBL30509659 | 0.85 | CHRM1 (1.00) | CHRM1SLC6A2SLC6A4SLC6A3CXCL8 | |
| Fenclofenac SCHEMBL29438086 | 0.85 | CHRM1 (1.00) | CHRM1SLC6A2SLC6A4SLC6A3CXCL8 | |
| Fenclofenac SCHEMBL25161 | 0.85 | CHRM1 (1.00) | CHRM1SLC6A2SLC6A4SLC6A3CXCL8 | |
| Fenclofenac SCHEMBL9692633 | 0.83 | CHRM1 (0.97) | CHRM1SLC6A2SLC6A4SLC6A3CXCL8 | |
| SCHEMBL29531142 | 0.82 | HSD17B10 (0.54) | CHRM1GAAMEN1LMNAKMT2A | |
| SCHEMBL1678581 | 0.82 | HSD17B10 (0.54) | CHRM1GAAMEN1LMNAKMT2A | |
| SCHEMBL3870178 | 0.79 | HSD17B10 (0.68) | CHRM1GAAMEN1LMNAKMT2A | |
| SCHEMBL155982 | 0.79 | HSD17B10 (0.61) | CXCL8MEN1LMNAKMT2ATTR | |
| SCHEMBL29431297 | 0.79 | HSD17B10 (0.61) | CXCL8MEN1LMNAKMT2ATTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB (HR) | 2009-09-03 | — | — | US | disclosed |
| EP-1846414-A1 | TETRACYCLIC MONOAMINE REUPTAKE INHIBITORS FOR TREATMENT OF CNS DISEASES AND DISORDERS | GlaxoSmithKline istrazivacki centar Zagreb d.o.o. (HR) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006109190-A1 | TETRACYCLIC MONOAMINE REUPTAKE INHIBITORS FOR TREATMENT OF CNS DISEASES AND DISORDERS | GLAXOSMITHKLINE ISTRAZIVACKI CENTAR ZAGREB D.O.O. (US) | 2006-10-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221687-A1 | Tetracyclic Monoamine Reuptake Inhibitors for Treatment of Cns Diseases and Disorders | MAOB, MAOA, TPH1 | CHRM1 378/4885SLC6A2 8/4885SLC6A4 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.