SCHEMBL25162018

SCHEMBL25162018

Cc1ccc(C(C)c2ccc(N)c(C)c2)cc1C

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 8/20 0.46
ALDH1A1 P00352 7/20 0.46
TDP1 Q9NUW8 7/20 0.46
TSHR P16473 4/20 0.46
MAPK1 P28482 1/20 0.41
LMNA P02545 1/20 0.38
S100B P04271 1/20 0.37
CASP1 P29466 1/20 0.37
TRPA1 O75762 1/20 0.36
PTGS1 P23219 1/20 0.36
CACNA1C Q13936 1/20 0.36
SKP2 Q13309 1/20 0.36
HIF1A Q16665 2/20 0.35
GAA P10253 1/20 0.35
ALOX12 P18054 1/20 0.35
HTT P42858 1/20 0.35
THRB P10828 2/20 0.35
ALOX15 P16050 2/20 0.35
RECQL P46063 1/20 0.35
TP53 P04637 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2154021 0.94 CYP3A4 (0.52) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL3482831 0.91 CYP3A4 (0.50) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL29352459 0.87 LMNA (0.46) ALDH1A1TDP1TSHRLMNATRPA1
SCHEMBL30475871 0.87 LMNA (0.46) ALDH1A1TDP1TSHRLMNATRPA1
SCHEMBL2336888 0.87 LMNA (0.46) ALDH1A1TDP1TSHRLMNATRPA1
SCHEMBL6033966 0.80 ALDH1A1 (0.54) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL11468860 0.80 ALDH1A1 (0.41) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL22044383 0.79 ALDH1A1 (0.48) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL5166514 0.78 CYP3A4 (0.54) CYP3A4ALDH1A1TDP1TSHRMAPK1
SCHEMBL1596340 0.78 CYP3A4 (0.54) CYP3A4ALDH1A1TDP1TSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230119573-A1 GAS SEPARATION MEMBRANE, GAS SEPARATION MODULE, GAS SEPARATION APPARATUS, AND POLYIMIDE COMPOUND FUJIFILM CORPORATION (JP) 2023-04-20 US disclosed