Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 9/20 | 0.43 |
| ▸ | F13A1 | P00488 | 8/20 | 0.43 |
| ▸ | TGM1 | P22735 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | GALR2 | O43603 | 1/20 | 0.36 |
| ▸ | GALR1 | P47211 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30371622 | 0.95 | F13A1 (0.39) | TGM2F13A1TGM1ALDH1A1LMNA | |
| SCHEMBL30371993 | 0.91 | HDAC8 (0.36) | TGM2F13A1TGM1ALDH1A1LMNA | |
| SCHEMBL30372119 | 0.90 | F13A1 (0.35) | TGM2F13A1TGM1ALDH1A1LMNA | |
| SCHEMBL30167909 | 0.89 | IGF1R (0.37) | ALDH1A1LMNATSHRSMN1; SMN2AURKA | |
| SCHEMBL24105245 | 0.89 | AURKA (0.37) | ALDH1A1LMNATSHRSMN1; SMN2AURKA | |
| SCHEMBL24105207 | 0.89 | IGF1R (0.37) | ALDH1A1LMNATSHRSMN1; SMN2AURKA | |
| SCHEMBL30167884 | 0.89 | AURKA (0.37) | ALDH1A1LMNATSHRSMN1; SMN2AURKA | |
| SCHEMBL24105243 | 0.88 | PTK6 (0.40) | ALDH1A1LMNASMN1; SMN2AURKAAURKB | |
| SCHEMBL30167771 | 0.88 | PTK6 (0.40) | ALDH1A1LMNASMN1; SMN2AURKAAURKB | |
| SCHEMBL25447758 | 0.87 | AURKA (0.38) | ALDH1A1LMNATSHRSMN1; SMN2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2023-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230141403-A1 | NOVEL IMIDAZOPYRAZINE DERIVATIVES | XDH, MYD88, IKZF3 | TGM2 3819/4885F13A1 1661/4885TGM1 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.