Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24105207 | 1.00 | IGF1R (0.37) | IGF1RAURKAAURKBPTK6ALDH1A1 | |
| SCHEMBL24105245 | 0.91 | AURKA (0.37) | AURKAAURKBPTK6ALDH1A1LMNA | |
| SCHEMBL30167884 | 0.91 | AURKA (0.37) | AURKAAURKBPTK6ALDH1A1LMNA | |
| SCHEMBL25170927 | 0.89 | TGM2 (0.43) | AURKAAURKBPTK6ALDH1A1LMNA | |
| SCHEMBL24105243 | 0.87 | PTK6 (0.40) | AURKAAURKBPTK6ALDH1A1LMNA | |
| SCHEMBL30167771 | 0.87 | PTK6 (0.40) | AURKAAURKBPTK6ALDH1A1LMNA | |
| SCHEMBL25170711 | 0.87 | KMT2A (0.38) | AURKAAURKBPTK6ALDH1A1LMNA | |
| SCHEMBL25447758 | 0.87 | AURKA (0.38) | AURKAAURKBPTK6ALDH1A1LMNA | |
| SCHEMBL24105198 | 0.86 | PTK6 (0.41) | AURKAAURKBPTK6ALDH1A1KMT2A | |
| SCHEMBL30167729 | 0.86 | PTK6 (0.41) | AURKAAURKBPTK6ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | claimed |
| CN-115667264-A | Novel imidazo-pyrazine derivatives | 豪夫迈·罗氏有限公司 | 2023-01-31 | — | — | CN | disclosed |