Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.42 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PPARD | Q03181 | 3/20 | 0.37 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25174338 | 0.91 | LMNA (0.46) | KDM4ENPSR1MAPTGAAMAPK1 | |
| SCHEMBL25479342 | 0.86 | KDM4E (0.47) | KDM4ENPSR1MAPTGAAMAPK1 | |
| SCHEMBL25479341 | 0.84 | KDM4E (0.46) | KDM4ENPSR1MAPTGAAMAPK1 | |
| SCHEMBL9228112 | 0.80 | NPSR1 (0.58) | KDM4ENPSR1MAPTGAAMAPK1 | |
| SCHEMBL9279562 | 0.79 | NPSR1 (0.72) | KDM4ENPSR1MAPTGAAMAPK1 | |
| SCHEMBL9230980 | 0.78 | NPSR1 (0.53) | KDM4ENPSR1MAPTGAAMAPK1 | |
| SCHEMBL25479257 | 0.77 | NPSR1 (0.49) | KDM4ENPSR1MAPTGAAMAPK1 | |
| SCHEMBL30442001 | 0.77 | NPSR1 (0.44) | KDM4ENPSR1MAPTGAATDP2 | |
| SCHEMBL25187350 | 0.77 | NPSR1 (0.44) | KDM4ENPSR1MAPTGAATDP2 | |
| SCHEMBL25188509 | 0.73 | GAA (0.41) | KDM4ENPSR1GAALMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4429663-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS | Vigil Neuroscience, Inc. (US) | 2024-09-18 | — | — | EP | disclosed |
| WO-2023086799-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |
| WO-2023086799-A1 | HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS | VIGIL NEUROSCIENCE, INC. (US) | 2023-05-19 | — | — | WO | disclosed |