Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.53 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.49 |
| ▸ | USP30 | Q70CQ3 | 3/20 | 0.48 |
| ▸ | STS | P08842 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | CCR2 | P41597 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30371872 | 1.00 | NOTUM (0.53) | NOTUMGPR119LMNAHTTUSP2 | |
| SCHEMBL13613090 | 0.86 | POLB (0.55) | NOTUMGPR119LMNAHTTUSP2 | |
| SCHEMBL13758488 | 0.86 | POLB (0.55) | NOTUMGPR119LMNAHTTUSP2 | |
| SCHEMBL2187327 | 0.81 | POLB (0.71) | NOTUMGPR119LMNAHTTUSP2 | |
| SCHEMBL22499987 | 0.81 | NOTUM (0.57) | NOTUMLMNAHTTUSP2MAPK1 | |
| SCHEMBL29689683 | 0.81 | NOTUM (0.57) | NOTUMLMNAHTTUSP2MAPK1 | |
| SCHEMBL4329546 | 0.79 | POLB (0.61) | NOTUMLMNAHTTUSP2MAPK1 | |
| SCHEMBL21542308 | 0.79 | ALDH1A1 (0.65) | GPR119LMNAHTTMAPK1POLB | |
| SCHEMBL21856300 | 0.79 | EPHX2 (0.53) | HTTMAPK1POLBEPHX2MAPT | |
| SCHEMBL21958729 | 0.79 | EPHX2 (0.53) | HTTMAPK1POLBEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023081662-A1 | BICYCLIC DERIVATIVES AS CCR2 MODULATORS | ARIA PHARMACEUTICALS, INC. (US) | 2023-05-11 | — | — | WO | disclosed |