Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.55 |
| ▸ | CCR2 | P41597 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13613090 | 1.00 | POLB (0.55) | POLBCCR2KCNH2NOTUMLMNA | |
| SCHEMBL22499987 | 0.88 | NOTUM (0.57) | POLBNOTUMLMNAUSP2SMN1; SMN2 | |
| SCHEMBL29689683 | 0.88 | NOTUM (0.57) | POLBNOTUMLMNAUSP2SMN1; SMN2 | |
| SCHEMBL4329546 | 0.86 | POLB (0.61) | POLBCCR2KCNH2NOTUMLMNA | |
| SCHEMBL25174352 | 0.86 | NOTUM (0.53) | POLBCCR2KCNH2NOTUMLMNA | |
| SCHEMBL30371872 | 0.86 | NOTUM (0.53) | POLBCCR2KCNH2NOTUMLMNA | |
| SCHEMBL18901609 | 0.84 | POLB (0.61) | POLBLMNAUSP2SMN1; SMN2TSHR | |
| SCHEMBL13613084 | 0.81 | CCR2 (0.54) | CCR2KCNH2SYK | |
| SCHEMBL2187327 | 0.81 | POLB (0.71) | POLBNOTUMLMNAUSP2SMN1; SMN2 | |
| SCHEMBL6792840 | 0.81 | KDM4D (0.47) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576089-B2 | 3-cycloalkylaminopyrrolidine derivatives as modulators of chemokine receptors | INCYTE CORPORATION | 2009-08-18 | — | — | US | disclosed |