SCHEMBL251774

SCHEMBL251774

FC(F)=C(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)F

nearest known ligand 0.34

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.34
TSHR P16473 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 2/20 0.32
HTT P42858 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15352141 1.00 KDM4E (0.34) KDM4ETSHRTDP1L3MBTL1HTT
SCHEMBL15351710 1.00 KDM4E (0.34) KDM4ETSHRTDP1L3MBTL1HTT
SCHEMBL15352692 1.00 KDM4E (0.34) KDM4ETSHRTDP1L3MBTL1HTT
SCHEMBL16414932 1.00 KDM4E (0.34) KDM4ETSHRTDP1L3MBTL1HTT
SCHEMBL249711 0.98 KDM4E (0.35) KDM4ETSHRTDP1
SCHEMBL251092 0.90 KDM4E (0.37) KDM4ETSHRTDP1
SCHEMBL29700985 0.82 THRB (0.35)
SCHEMBL5626548 0.82 THRB (0.35)
SCHEMBL1593172 0.80 TSHR (0.37) KDM4ETSHRTDP1L3MBTL1HTT
SCHEMBL1827807 0.80 TSHR (0.37) KDM4ETSHRTDP1L3MBTL1HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3059235-B1 TETRAZOLINONE DERIVATIVES AND THEIR USE FOR CONTROLLING PESTS SUMITOMO CHEMICAL CO (JP) 2020-10-28 EP disclosed
US-10085450-B2 Tetrazolinone compound and use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2018-10-02 US disclosed
EP-2841433-B1 TETRAZOLINONE COMPOUNDS AND ITS USE SUMITOMO CHEMICAL CO (JP) 2017-06-21 EP disclosed
US-20160270399-A1 TETRAZOLINONE COMPOUND AND USE THEREOF SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-09-22 US disclosed
EP-3059235-A1 TETRAZOLINONE COMPOUND AND APPLICATION FOR SAME Sumitomo Chemical Company, Ltd. (JP) 2016-08-24 EP disclosed
US-9380782-B2 Tetrazolinone compounds and its use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2016-07-05 US disclosed
EP-2841433-A1 TETRAZOLINONE COMPOUNDS AND ITS USE Sumitomo Chemical Company Limited (JP) 2015-03-04 EP disclosed
US-20150031733-A1 TETRAZOLINONE COMPOUNDS AND ITS USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2015-01-29 US disclosed
WO-2013162077-A1 TETRAZOLINONE COMPOUNDS AND ITS USE SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2013-10-31 WO disclosed
US-8399723-B2 Processes for production and purification of hydrofluoroolefins E I DU PONT DE NEMOURS AND COMPANY (US) 2013-03-19 US disclosed
EP-0273763-B1 FLUORINE-CONTAINING POLYMERS AND OXYGEN-PERMEATING ARTICLES COMPOSED OF SAID POLYMERS MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1993-02-24 EP disclosed
US-5057585-A Contact lenses MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1991-10-15 US disclosed
US-5055601-A Epoxidizing fluoroolefin with hypochlorite in basic two phase system containing lipophilic phase transfer catalyst ASAHI KASEI KOGYO K.K. (JP) 1991-10-08 US disclosed
US-4965379-A EPOXIDATION OF FLUOROOLEFIN ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) 1990-10-23 US disclosed
US-4957985-A ACRYLATED POLYOXYALKYLENE GLYCOLS, CONTACT LENSES MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1990-09-18 US disclosed
EP-0100488-B1 FLUOROEPOXIDES AND A PROCESS FOR PRODUCTION THEREOF Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1987-03-04 EP disclosed
EP-0100488-A1 Fluoroepoxides and a process for production thereof Asahi Kasei Kogyo Kabushiki Kaisha (JP) 1984-02-15 EP disclosed
EP-0003328-B1 STABILIZED ETHYLENE-TETRAFLUOROETHYLENE-TYPE COPOLYMERS, PROCESS FOR PREPARING THEM AND THEIR USE HOECHST AKTIENGESELLSCHAFT (DE) 1982-03-24 EP disclosed
US-4267098-A OPTIONALLY ALSO CONTAINING A COPOLYMERIZABLE MONOMER AND PHOSPHORUS ACID SALTS HOECHST AKTIENGESELLSCHAFT (DE) 1981-05-12 US disclosed
EP-0003328-A1 Stabilized ethylene-tetrafluoroethylene-type copolymers, process for preparing them and their use HOECHST AKTIENGESELLSCHAFT (DE) 1979-08-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10085450-B2 Tetrazolinone compound and use thereof ROS1, TCOF1, RPS20 KDM4E 1468/4885TSHR 286/4885TDP1 3166/4885
US-20150031733-A1 TETRAZOLINONE COMPOUNDS AND ITS USE CBR3, CYP51A1, CYP8B1 KDM4E 2844/4885TSHR 110/4885TDP1 3755/4885
US-20160270399-A1 TETRAZOLINONE COMPOUND AND USE THEREOF ROS1, TCOF1, RPS20 KDM4E 1468/4885TSHR 286/4885TDP1 3166/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.