Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 9/20 | 0.53 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL503631 | 0.84 | MAPT (0.58) | HDAC2HDAC8HDAC6HDAC3MAPK1 | |
| SCHEMBL2518011 | 0.84 | MAPT (0.58) | HDAC2HDAC8HDAC6HDAC3MAPK1 | |
| SCHEMBL2523030 | 0.84 | MAPT (0.58) | HDAC2HDAC8HDAC6HDAC3MAPK1 | |
| SCHEMBL3730290 | 0.83 | GPR52 (0.50) | GPR52KEAP1ALDH1A1HDAC2HDAC8 | |
| SCHEMBL27548545 | 0.79 | GPR52 (0.51) | GPR52KEAP1ALDH1A1HDAC2HDAC8 | |
| SCHEMBL2853636 | 0.78 | GPR52 (0.70) | GPR52 | |
| SCHEMBL2853640 | 0.78 | GPR52 (0.70) | GPR52 | |
| SCHEMBL2856224 | 0.78 | GPR52 (0.70) | GPR52 | |
| SCHEMBL7518761 | 0.78 | GPR52 (0.48) | GPR52KEAP1ALDH1A1HDAC2HDAC8 | |
| Maleic Acid SCHEMBL4301221 | 0.76 | ALDH1A1 (0.66) | GPR52KEAP1ALDH1A1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0903337-B1 | PROCESS FOR THE PREPARATION OF 1-ALKOXYCARBONYL-3-PHENYLPROPYL DERIVATIVES | KANEKA CORP (JP) | 2006-04-12 | — | — | EP | claimed |
| US-6479492-B1 | TREATMENT OF INFLAMMATORY DISEASES IN A MAMMALIAN PATIENT | ELAN PHARMACEUTICALS, INC. | 2002-11-12 | — | — | US | claimed |
| EP-1179529-A1 | NOVEL HYDROXAMIC ACID DERIVATIVES | Daiichi Fine Chemical Co., Ltd. (JP) | 2002-02-13 | — | — | EP | claimed |
| EP-1038864-A1 | NOVEL METALLOPROTEINASE INHIBITORS | FUJI YAKUHIN KOGYO KABUSHIKI KAISHA (JP) | 2000-09-27 | — | — | EP | claimed |
| US-6118010-A | CATALYTIC REDUCTION OF THE 1-ALKOXYCARBONYL-3-OXO-3-PHENYLPROPYL DERIVATIVE | KANEKA CORPORATION (JP) | 2000-09-12 | — | — | US | claimed |
| EP-0903337-A1 | PROCESS FOR THE PREPARATION OF 1-ALKOXYCARBONYL-3-PHENYLPROPYL DERIVATIVES | KANEKA CORPORATION (JP) | 1999-03-24 | — | — | EP | claimed |
| EP-0187956-A2 | Pharmaceutical composition for the treatment of defects of the gastrointestinal mucous membrane | BOEHRINGER INGELHEIM KG (DE) | 1986-07-23 | — | — | EP | claimed |
| US-20110247523-A1 | ORGANIC-INORGANIC COMPOSITE PARTICLES, PARTICLE DISPERSION, PARTICLE-DISPERSED RESIN COMPOSITION, AND METHOD FOR PRODUCING ORGANIC-INORGANIC COMPOSITE PARTICLES | TOHOKU UNIVERSITY (JP) | 2011-10-13 | — | — | US | disclosed |
| CN-102112115-A | Modified release ramipril compositions and uses thereof | PANACEA BIOTEC LTD | 2011-06-29 | — | — | CN | disclosed |
| CN-1530102-B | Medical preparation containing alpha-thioctan, ambroxol and/or ACE inhibiting agent and its use in treating neurodegenerative diseases | MAIN NERVE TECHNOLOGY AG | 2010-12-08 | — | — | CN | disclosed |
| EP-1679303-B1 | Process for preparing 1-alkoxycarbonyl-3-phenylpropyl derivative | KANEKA CORP (JP) | 2010-09-15 | — | — | EP | disclosed |
| CN-101489550-A | Stable pharmaceutical compositions of 2-aza-bicyclo [3.3.0] -octane-3-carboxylic acid derivatives | TEVA PHARMA (IL) | 2009-07-22 | — | — | CN | disclosed |
| US-7538215-B2 | Compounds which inhibit leukocyte adhesion mediated by VLA-4 | ELAN PHARMACEUTICALS, INC. (US) | 2009-05-26 | — | — | US | disclosed |
| WO-1997045422-A1 | ANTI-NEURODEGENERATIVELY EFFECTIVE 10-AMINOALIPHATYL-DIBENZ[b,f]OXEPINE SALTS | NOVARTIS AG (CH) | 1997-12-04 | — | — | WO | disclosed |
| US-5677281-A | ADMINISTERING ARALKYLPHOSPHONYL TRIPEPTIDE TO INHIBIT SPECIFIED ENDOPEPTIDASES | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1997-10-14 | — | — | US | disclosed |
| CN-1127504-A | Substituted 2-phenylpyridines with herbicidal action | BASF AG (DE) | 1996-07-24 | — | — | CN | disclosed |
| EP-0565450-A1 | Use of peptide derivatives for the manufacture of medicaments inhibiting endopeptidases 24.15 and 24.16 | COMMISSARIAT A L'ENERGIE ATOMIQUE (FR) | 1993-10-13 | — | — | EP | disclosed |
| EP-0336368-A2 | N2-(1-carboxy-3-phenylpropyl)-L-lysine derivative and process of producing lysinopril using the compound | KANEGAFUCHI KAGAKU KOGYO KABUSHIKI KAISHA (JP) | 1989-10-11 | — | — | EP | disclosed |
| EP-0187956-A2 | Pharmaceutical composition for the treatment of defects of the gastrointestinal mucous membrane | BOEHRINGER INGELHEIM KG (DE) | 1986-07-23 | — | — | EP | disclosed |
| US-4602002-A | N-carboxymethyl substituted lysyl and α-(ε-aminoalkyl) glycyl amino acid antihypertensive agents | MERCK & CO., INC. (US) | 1986-07-22 | — | — | US | disclosed |