Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.52 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.66 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.58 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Biphenyl SCHEMBL4074902 | 0.93 | ALDH1A1 (0.59) | ALDH1A1TAAR1HCAR2LMNACYP2D6 | |
| Cinnamic Acid SCHEMBL890441 | 0.85 | HCAR2 (0.76) | ALDH1A1HCAR2LMNACYP2D6CYP2C19 | |
| SCHEMBL23854259 | 0.83 | HDAC3 (0.67) | HCAR2FFAR1HDAC1HDAC3HDAC4 | |
| SCHEMBL3225302 | 0.83 | HDAC3 (0.67) | HCAR2FFAR1HDAC1HDAC3HDAC4 | |
| Butylbenzyl SCHEMBL28319138 | 0.83 | ATG4B (0.63) | ALDH1A1TAAR1HCAR2TDP1 | |
| SCHEMBL2856224 | 0.82 | GPR52 (0.70) | GPR52 | |
| SCHEMBL2853640 | 0.82 | GPR52 (0.70) | GPR52 | |
| SCHEMBL2853636 | 0.82 | GPR52 (0.70) | GPR52 | |
| Phenylacetic Acid SCHEMBL30960397 | 0.81 | AKR1B1 (0.77) | ALDH1A1TAAR1HCAR2LMNACYP2D6 | |
| Benzylamine SCHEMBL8533927 | 0.81 | LOXL2 (0.64) | ALDH1A1TAAR1HCAR2LMNACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153737-A | The manufacturing method of terminal-modified conjugated diolefin polymer, rubber composition, rubber product and terminal-modified conjugated diolefin polymer | 株式会社普利司通 | 2019-01-04 | — | — | CN | disclosed |
| CN-103044921-B | Photo curable organopolysiloxane composition | 信越化学工业株式会社 | 2017-03-01 | — | — | CN | disclosed |
| US-20090267489-A1 | GAS BARRIER THIN FILM LAMINATE, GAS BARRIER RESIN SUBSTRATE AND ORGANIC EL DEVICE | KONICA MINOLTA HOLDINGS, INC. (JP) | 2009-10-29 | — | — | US | disclosed |