SCHEMBL25181401

SCHEMBL25181401

COC(=O)C(CNC(=O)c1cc(CBr)nc(CBr)c1)CNC(=O)c1cc(CBr)nc(CBr)c1

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ F10 P00742 1/20 0.38
▸ PRSS1 P07477 1/20 0.38
▸ KMT2A Q03164 5/20 0.36
▸ GAA P10253 3/20 0.36
▸ HSD17B10 Q99714 1/20 0.36
▸ MEN1 O00255 3/20 0.35
▸ KDM4E B2RXH2 4/20 0.35
▸ ALDH1A1 P00352 4/20 0.35
▸ RXFP1 Q9HBX9 1/20 0.35
▸ TP53 P04637 1/20 0.34
▸ MAPK10 P53779 1/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ POLB P06746 1/20 0.34
▸ MAPT P10636 1/20 0.34
▸ RECQL P46063 1/20 0.34
▸ TAS1R3 Q7RTX0 1/20 0.33
▸ TAS1R1 Q7RTX1 1/20 0.33
▸ HPGD P15428 2/20 0.33
▸ OPRM1 P35372 1/20 0.33
▸ OPRD1 P41143 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26229683 0.90 KDM5B (0.35) F10PRSS1KMT2AGAAHSD17B10
SCHEMBL25186961 0.87 F10 (0.38) F10PRSS1KMT2AGAAHSD17B10
SCHEMBL26228742 0.87 F10 (0.38) F10PRSS1KMT2AGAAHSD17B10
SCHEMBL26228739 0.85 HSD17B10 (0.37) KMT2AGAAHSD17B10MEN1KDM4E
SCHEMBL25182494 0.85 TAS1R3 (0.45) TAS1R3TAS1R1
SCHEMBL25182492 0.84 GAA (0.35) KMT2AGAAHSD17B10KDM4EALDH1A1
SCHEMBL26230874 0.82 GAA (0.42) KMT2AGAAHSD17B10KDM4EALDH1A1
SCHEMBL25191067 0.79 F10 (0.34) F10PRSS1KMT2AGAAHSD17B10
SCHEMBL23395745 0.75 KDM4E (0.37) KMT2AGAAMEN1KDM4EALDH1A1
SCHEMBL26229684 0.75 KDM4E (0.37) KMT2AGAAHSD17B10KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230277678-A1 COMPOUNDS CAPABLE OF BINDING TO PROTEINS AND CONJUGATES OBTAINED FROM THESE COMPOUNDS MC SAF (FR) 2023-09-07 — — US disclosed
US-20230277678-A1 COMPOUNDS CAPABLE OF BINDING TO PROTEINS AND CONJUGATES OBTAINED FROM THESE COMPOUNDS MC SAF (FR) 2023-09-07 — — US disclosed
EP-4181964-A1 COMPOUNDS CAPABLE OF BINDING TO PROTEINS AND CONJUGATES OBTAINED FROM THESE COMPOUNDS Mc SAF (FR) 2023-05-24 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230277678-A1 COMPOUNDS CAPABLE OF BINDING TO PROTEINS AND CONJUGATES OBTAINED FROM THESE COMPOUNDS SHBG, SERPINA6, F13B F10 192/4885PRSS1 1479/4885KMT2A 4179/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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