Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.57 |
| ▸ | PRKCI | P41743 | 1/20 | 0.57 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | EGLN2 | Q96KS0 | 3/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.39 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30375279 | 1.00 | ALDH1A1 (0.57) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25198709 | 0.84 | HSD17B10 (0.49) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375027 | 0.82 | HAO1 (0.44) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25180455 | 0.82 | HAO1 (0.44) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25173842 | 0.79 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375726 | 0.79 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25183258 | 0.79 | ALDH1A1 (0.46) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375154 | 0.77 | ALDH1A1 (0.42) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25202577 | 0.77 | ALDH1A1 (0.42) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25184055 | 0.77 | ALDH1A1 (0.44) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426681-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | Sitryx Therapeutics Limited (GB) | 2024-09-11 | — | — | EP | disclosed |
| CN-118317951-A | Phthalazine derivatives as pyruvate kinase modulators | 西特瑞治疗有限公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |