Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | PRKCI | P41743 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25173842 | 1.00 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25180455 | 0.83 | HAO1 (0.44) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375027 | 0.83 | HAO1 (0.44) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25183266 | 0.79 | ALDH1A1 (0.57) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375279 | 0.79 | ALDH1A1 (0.57) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL24076270 | 0.72 | ALDH1A1 (0.47) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL29655133 | 0.72 | ALDH1A1 (0.47) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375367 | 0.72 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25200648 | 0.72 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL1009542 | 0.70 | HSD17B10 (0.51) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426681-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | Sitryx Therapeutics Limited (GB) | 2024-09-11 | — | — | EP | disclosed |
| CN-118317951-A | Phthalazine derivatives as pyruvate kinase modulators | 西特瑞治疗有限公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |