Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 3/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.32 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.32 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.32 |
| ▸ | FER | P16591 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25202577 | 1.00 | ALDH1A1 (0.42) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30904942 | 0.91 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375267 | 0.78 | KDM5B (0.37) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25173866 | 0.78 | KDM5B (0.37) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25179975 | 0.78 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30376022 | 0.78 | ALDH1A1 (0.41) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL25183266 | 0.77 | ALDH1A1 (0.57) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30375279 | 0.77 | ALDH1A1 (0.57) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30904943 | 0.77 | DUT (0.33) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 | |
| SCHEMBL30904940 | 0.77 | DUT (0.33) | ALDH1A1PARP1PRKCIPDE4BHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4426681-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | Sitryx Therapeutics Limited (GB) | 2024-09-11 | — | — | EP | disclosed |
| CN-118317951-A | Phthalazine derivatives as pyruvate kinase modulators | 西特瑞治疗有限公司 | 2024-07-09 | — | — | CN | disclosed |
| WO-2023079294-A1 | PHTHALAZINE DERIVATIVES AS PYRUVATE KINASE MODULATORS | SITRYX THERAPEUTICS LIMITED (GB) | 2023-05-11 | — | — | WO | disclosed |