Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.76 |
| ▸ | GAA | P10253 | 8/20 | 0.76 |
| ▸ | STS | P08842 | 2/20 | 0.74 |
| ▸ | CA2 | P00918 | 1/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.66 |
| ▸ | HPGD | P15428 | 5/20 | 0.66 |
| ▸ | GLA | P06280 | 7/20 | 0.63 |
| ▸ | ALPL | P05186 | 3/20 | 0.63 |
| ▸ | ALPI | P09923 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | ALDH2 | P05091 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | CA12 | O43570 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30139608 | 1.00 | ALDH1A1 (0.76) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL3761326 | 0.99 | ALDH1A1 (0.74) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL10850187 | 0.87 | KDM4E (1.00) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL38662608 | 0.85 | ALDH1A1 (0.76) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL9451464 | 0.85 | STS (1.00) | ALDH1A1KDM4EGAASTSCA2 | |
| Potassium Ion SCHEMBL380405 | 0.84 | KDM4E (0.74) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL3761324 | 0.84 | KDM4E (0.74) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL10850733 | 0.83 | MAOB (0.70) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL1358798 | 0.83 | KDM4E (0.72) | ALDH1A1KDM4EGAASTSCA2 | |
| SCHEMBL13930283 | 0.82 | MAOB (0.71) | ALDH1A1KDM4EGAASTSCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 660 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11332490-B1 | Compounds and methods for treating osteoarthritis | ACADEMIA SINICA (TW) | 2022-05-17 | — | — | US | claimed |
| EP-3911737-A1 | ENGINEERED ARYL SULFATE-DEPENDENT ENZYMES | Optimvia, LLC (US) | 2021-11-24 | — | — | EP | claimed |
| CN-113646427-A | Engineered arylsulfate-dependent enzymes | 奥普蒂姆维亚有限公司 | 2021-11-12 | — | — | CN | claimed |
| US-20210231645-A1 | METHODS AND COMPOSITIONS FOR INVESTIGATING MULTIPLE DRUG-DRUG TRANSPORTER INTERACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY | 2021-07-29 | — | — | US | claimed |
| WO-2021119326-A1 | METHODS AND COMPOSITIONS FOR INVESTIGATING MULTIPLE DRUG-DRUG TRANSPORTER INTERACTIONS | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2021-06-17 | — | — | WO | claimed |
| WO-2021061517-A1 | ASSAY OF ARYLSULFATASE A ENZYMATIC ACTIVITY IN DRIED BLOOD SPOTS BY MASS SPECTROMETRY AND FLUOROMETRY | UNIVERSITY OF WASHINGTON (US) | 2021-04-01 | — | — | WO | claimed |
| WO-2020218950-A1 | COMBINATION FOR TREATING FUNCTIONAL DISEASES OF THE GASTROINTESTINAL TRACT | ОБЩЕСТВО С ОГРАНИЧЕННОЙ ОТВЕТСТВЕННОСТЬЮ "ВАЛЕНТА-ИНТЕЛЛЕКТ" | 2020-10-29 | — | — | WO | claimed |
| WO-2020194563-A1 | AGENT FOR PREVENTING OR IMPROVING SYMPTOMS OR DISEASE CAUSED BY PHENOLS | 国立大学法人東北大学 | 2020-10-01 | — | — | WO | claimed |
| WO-2020150350-A1 | ENGINEERED ARYL SULFATE-DEPENDENT ENZYMES | OPTIMVIA, LLC (US) | 2020-07-23 | — | — | WO | claimed |
| US-10605803-B2 | Composition for enzyme immunoassay using immunofluorescence and uses thereof | BIOMERIEUX (FR) | 2020-03-31 | — | — | US | claimed |
| EP-1379662-A2 | SULFATASES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2004-01-14 | — | — | EP | claimed |
| US-20030148920-A1 | Sulfatases and methods of use thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2003-08-07 | — | — | US | claimed |
| US-20030147875-A1 | Sulfatases and methods of use thereof | NIH-DEITR | 2003-08-07 | — | — | US | claimed |
| WO-2002059327-A2 | SULFATASES AND METHODS OF USE THEREOF | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2002-08-01 | — | — | WO | claimed |
| WO-2002018539-A2 | METHOD FOR ASSAYING THE ACTIVITY OF LYSOSOMAL ENZYMES | LYSOMETRIX CORPORATION (US) | 2002-03-07 | — | — | WO | claimed |
| US-6225100-B1 | ENZYME FROM CLOSTRIDIUM WITH STORAGE AND REACTION STABILITY; FOR EFFICIENT SULFATION OF TYROSYLPEPTIDES SUCH AS CHOLECYSTOKININ | DCV, INC. | 2001-05-01 | — | — | US | claimed |
| WO-1998003636-A9 | NOVEL ARYLSULFOTRANSFERASE | — | 1998-05-22 | — | — | WO | claimed |
| WO-1998003636-A1 | NOVEL ARYLSULFOTRANSFERASE | BIO-TECHNICAL RESOURCES (US) | 1998-01-29 | — | — | WO | claimed |
| US-5094944-A | Umbelliferyl containing substrates | HAYES KENNETH R (US) | 1992-03-10 | — | — | US | claimed |
| WO-1990012886-A1 | FLUORESCENT AQUATIC BIOASSAY AND PROCEDURE | HAYES KENNETH R (US) | 1990-11-01 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11332490-B1 | Compounds and methods for treating osteoarthritis | SULT1E1, STS, ARSA | ALDH1A1 288/4885KDM4E 1513/4885GAA 1581/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.